Iodine‐Catalyzed Oxidation of N‐Substituted Indoles by using Chloramine‐B: A Facile and Practical Approach to Isatins

Abstract An efficient method for the iodine‐catalyzed oxidation of N ‐substituted indoles by using chloramine‐B under mild reaction conditions was explored. This reaction was found to be tolerant to a variety of functional groups and provided the corresponding isatins in moderate to excellent yields. In addition, application of this method to the one‐pot synthesis of 3‐hydroxyoxindole and N ‐methylisatin oxime was realized.