Purine and Pyrimidine Analogues from the South China Sea Gorgonian Muricella flexuosa

Eleven compounds were isolated from the South China Sea gorgonian Muricella flexuosa by meanings of silica gel,Sephadex LH-20 column chromatography and recrystallization.Their structures were identified by physicochemical properties,spectroscopic analysis and comparison with the data of literatures.These 11 compounds were caffeine(1),1,7-diethylhypoxnathine(2),1-methylhypoxnathine(3),7,9-dimethy-6-(N-methyl)purine-8-one(4),7-ethyladenine(5),1,7-diethylpurine-6,8-dione(6),uracil(7),thymine(8),2′-deoxyuridine(9),2′-deoxythymidine(10),3-ethyl-2′-deoxythymidine(11).Compounds 2-6 and 11 were obtained from the genus Muricella for the first time,and 4 and 11 were isolated from nature for the first time.