Applications of hybrid organic–inorganic materials in chiral separation

Chiral separation has always been a topic concerned by chemical and pharmaceutical communities. Hybrid organic-inorganic materials (HOIM), with high mechanical stability, large surface area, tailored pore size, controlled morphology and organic loading have shown superior chiral recognition performance in several kinds of chiral separation technologies. In this review, application progress of HOIM used as chiral stationary phases for HPLC, CEC/CLC and GC was discussed in detail. The developments of HOIM applied in membrane separation and electrochemistry discrimination were also summarized.