产热素
产热
脂肪组织
白色脂肪组织
褐色脂肪组织
脂联素
生物
清脆的
FGF21型
内科学
内分泌学
细胞生物学
生物化学
肥胖
基因
医学
胰岛素抵抗
成纤维细胞生长因子
受体
作者
Qiantao Zheng,Jun Lin,Jiaojiao Huang,Hongyong Zhang,Rui Zhang,Xueying Zhang,Chenglong Cao,Catherine Hambly,Guosong Qin,Jing Yao,Ruigao Song,Qitao Jia,Xiao Wang,Yongshun Li,Nan Zhang,Zhengyu Piao,Rongcai Ye,John R. Speakman,Hongmei Wang,Qi Zhou,Yanfang Wang,Wanzhu Jin,Jianguo Zhao
标识
DOI:10.1073/pnas.1707853114
摘要
Significance Uncoupling protein 1 (UCP1) is responsible for brown adipose tissue-mediated thermogenesis and plays a critical role in protecting against cold and regulating energy homeostasis. Modern pigs lack functional UCP1, which makes them susceptible to cold and prone to fat deposition and results in neonatal mortality and decreased production efficiency. In the current study, a CRISPR/Cas9-mediated homologous recombination-independent approach was established, and mouse adiponectin-UCP1 was efficiently inserted into the porcine endogenous UCP1 locus. The resultant UCP1 KI pigs showed an improved ability to maintain body temperature, decreased fat deposition, and increased carcass lean percentage. UCP1 KI pigs are a potentially valuable resource for the pig industry that can improve pig welfare and reduce economic losses.
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