水通道蛋白
表皮(动物学)
丝状蛋白
人体皮肤
细胞生物学
角质形成细胞
水通道蛋白3
细胞内
水运
生物
生理学
体外
医学
生物化学
皮肤病科
水流
解剖
遗传学
工程类
环境工程
特应性皮炎
作者
Marc‐Emmanuel Dumas,Neil S. Sadick,Emmanuelle Noblesse,Milène Juan,Nadège Lachmann-Weber,Mathieu Boury-Jamot,Rachid Sougrat,Jean‐Marc Verbavatz,Sylvianne Schnebert,Frédéric Bonté
出处
期刊:Le Centre pour la Communication Scientifique Directe - HAL - Diderot
日期:2007-06-01
卷期号:6 (6 Suppl): s20-4
被引量:46
摘要
Aquaporins (AQPs) are proteins that facilitate the transport of water across cell membranes. AQP3 expression is related to the expressions of other epidermal proteins involved in water maintenance (ie, CD44, claudin-1, and filaggrin). The expressions of AQP3 water channels are strongly affected by age and chronic sun exposure, and a defective osmotic equilibrium could occur in the epidermis, which would account for the skin dryness observed in older people and skin areas most exposed to sunlight. We investigated active ingredients that are able to increase AQP3 levels in order to improve hydration in human skin keratinocytes. We selected an ethanolic/water (70/30 v/v) extract of Ajuga turkestanica, a plant from Central Asia, as the hydrating agent. After 17 days of treatment every 2 days with this extract (2.5 microg/mL) in vitro, AQP3 expression measured at the protein level in human reconstructed epidermis was significantly increased. Water transport through both aquaporins and aquaglyceroporins and glycerol transport through aquaglyceroporins alone are important to skin hydration. The distribution and the variability of aquaporins in human skin cells suggest that these channels may have important roles in skin physiology. AQPs appear to be key protein targets to improve the resistance and quality of the skin surface as well as to improve aging and sun exposure-induced dryness as shown by their roles in 1) hydrating the living layers of the epidermis where the keratinocyte differentiation takes place and 2) barrier formation and recovery.
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