Multiple Myeloma and Related Disorders

Part 1. History of multiple myeloma Epidemiology and etiology of plasma cell neoplasms Part 2. The immune system in myeloma Molecular biology and cytogenetics Biology of the malignant plasma cell Pathophysiology of myeloma bone disease Part 3. Clinical features Hematologic investigations: Morphologic and phenotypic Part 4. Biochemical and immunological investigations The role of imaging in multiple myeloma Innovative approaches for diagnosis and monitoring Differential diagnosis and prognosis Part 5. Principles of management Chemotherapy, steroids and interferon Radiotherapy Autologous stem cell transplantation Allogeneic transplantation and treatment with donor lymphocytes Supportive care Biological basis of therapy: New molecular targets Immunotherapeutic approaches Part 6. Management of bone disease Management of myeloma patients with renal failure Neurologic aspects of monoclonal gammopathy of undetermined significance, multiple myeloma, and related disorders Part 7. Monoclonal gammopathies of undetermined significance: the transition from MGUS to myeloma Solitary bone and extramedullary plasmacytoma Plasma cell leukaemia AL amyloidosis Heavy-chain diseases Waldenstroma (TM)s disease