乙基亚硝基脲
体内
化学
体外
细胞培养
药品
癌症研究
艾氏腹水癌
肿瘤细胞
药理学
立体化学
生物化学
生物
遗传学
基因
突变体
作者
A Pain,S Samanta,Sushanta Dutta,Ajit Kumar Saxena,M. Shanmugavel,Manmohan Sharma,G. N. Qazi,Utpal Sanyal
出处
期刊:PubMed
日期:2007-08-02
卷期号:64 (1): 27-33
被引量:1
摘要
Four new ethylnitrosourea derivatives of substituted naphthalimides 3a-d have been synthesized from the respective N-(2-ethylamino) naphthalimides. Their chemical alkylating activity compared with the clinical drug CCNU and an experimental compound Mitonafide indicated that they possess lower alkylating activity than CCNU and comparable activity with the latter. Their anti-tumor efficacies were assessed in vivo in two murine ascites tumors namely Sarcoma-180 (S-180) and Ehrlich ascites carcinoma (EAC) by measuring the increase in median survival times (MST) of drug treated (T) over untreated control (C) mice. CCNU and Mitonafide were used as positive controls for comparison. The representative compound 3a has displayed marginal anti-tumoral activity in these tumors. Three compounds were further screened in vitro in 4 different human tumor cell lines but no significant activity was observed in those lines. These compounds moderately inhibit the synthesis of DNA and RNA in S-180 tumor cells.
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