Correlative analysis of H-type hypertension and acute cerebral infarction

Objective To investigate the correlation between H-type hypertension and acute cerebral infarction.Methods A total of 220 consecutive patients with acute cerebral infarction diagnosed by head MRI were included in the study.At the same period,120 hospitalized patients with transient ischemic attack(TIA) whose cerebral infarction were excluded with head MRI were used as the control group.The age,hypertension,diabetes,hyperlipidemia,family history and other risk factors of the patients were documented.The fasting venous samples of all the subjects were collected at day 2 and 3 after the onset.The level of serum homocysteine(Hcy) was detected by using high-performance liquid chromatography.Using Hcy ≥10 μmol/L as the standard of high homocysteine(Hhcy),hypertensive patients with Hhcy were the H-type hypertension.The patients with the increased Hcy only were the simple Hhcy group,and the patients with elevated blood pressure only were the sample hypertension group.Results ① The Hcy levels of the patients in the cerebral infarction group was higher than those in the control group.The incidences of hypertension,Hhcy and H-type hypertension were higher than those in the control group.The differences were statistically significant(P0.01).②Among the 340 patients,the incidence of cerebral infarction in the hypertensive patients was higher than that in the normotensive subjects(χ2=10.290,P0.01);the incidence of cerebral infarction in patients with Hhcy was higher than that in patients with normal Hcy(χ2=27.396,P0.01).The incidence of cerebral infarction in patients with H-type hypertension(73.3%) was higher than that in the simple hypertension group(42.3%),the simple HHcy group(61.3%),and both blood pressure and Hcy were normal group(18.2%).The differences were statistically significant(P0.05 or P0.01).③Multivariate logistic regression analysis showed that the independent risk factors for acute cerebral infarction were H-type hypertension(OR,3.34,95%CI: 1.59-7.02) and Hhcy(OR,1.96,95% CI: 1.15-3.36).Conclusion The Hcy levels of the patients with acute cerebral infarction is elevated,and the patients with H-type hypertension has higher incidence of cerebral infarction,H-type hypertension may be an independent risk factor for stroke events.