增殖细胞核抗原
免疫组织化学
脾脏
肿瘤
抗原
细胞
药丸
肿瘤抗原
细胞生长
生物
癌症研究
免疫系统
化学
病理
免疫学
医学
药理学
免疫疗法
生物化学
作者
Xuhui Zhang,Dali Chen,Rongcheng Luo
出处
期刊:PubMed
日期:2006-12-01
卷期号:26 (12): 1791-3
被引量:2
摘要
To study the anti-tumor effect of Biejiajianwan pills and explore its mechanism.Mice bearing neoplasm induced by H22 cell inoculation were randomized into 4 groups, namely the negative control group, positive control group (with cyclophosphamide treatment), and high- and low-dose Biejiajianwan pill group. The tumor-bearing mice received corresponding treatments for 15 consecutive days, after which their thymuses and spleens were isolated and weighed to calculate the thymus and spleen indices. The tumor mass was also weighed and the tumor inhibition rate calculated. Immunohistochemistry was performed to evaluate the expression intensity of proliferating cell nuclear antigen (PCNA) in the tumor tissue.The pills significantly inhibited the growth of the implanted tumor and reduced the expression of PCNA in the tumor.One of the possible mechanisms of the anti-tumor effects of Biejiajian pills might be associated with the inhibition of PCNA expression in the tumor.
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