• Heart failure–related cardiogenic shock (HF-CS) has a distinct presentation compared with myocardial infarction–related cardiogenic shock. • Proactive use of invasive hemodynamics should be considered early in presentations of HF-CS. • HF-CS should be staged by severity and ventricular phenotype. • More data are needed to understand the comparative efficacy of various medical and mechanical support therapies in HF-CS.