光热治疗
材料科学
原位
纳米颗粒
癌症免疫疗法
纳米技术
级联
免疫疗法
癌症治疗
光热效应
癌症
化学工程
生物
有机化学
化学
工程类
遗传学
作者
Chenlu Huang,Hanyong Wang,Xinyu Yang,Qingyu Yu,Hai Wang,Linhua Zhang,Yanli Zhao,Dunwan Zhu
标识
DOI:10.1002/adfm.202401489
摘要
Abstract Rapid advances in nanotechnology have made it possible to combine photothermal therapy (PTT) with immunotherapy, enabling to activate an in situ vaccine effect. However, this effect is severely impeded by low antigen presentation level and highly suppressive tumor immune microenvironment (immune “cold” tumors). To overcome the obstacles, multifunctional carrier‐free nanoparticles (FCDP‐NPs) assembled from Fe 2+ , toll‐like receptor 9 agonist (CpG), cationic lipid (DOTAP) and photothermal agent polydopamine are developed. After intratumoral injection, FCDP‐NPs carrying positive charge are exposed under laser irradiation, which can capture tumor‐associated antigens (TAAs) generated upon post‐PTT to form the nanovaccines (FCD‐NPs@TAAs). The nanovaccines further promote cross‐presentation of TAAs, stimulate adaptive immune responses, and shape immune “hot” tumors. As a result, in situ nanovaccines highly improve survival rates and elicit a durable immune memory that remarkedly prevents tumor metastasis, illustrating a useful platform for PTT synergized with immunotherapy.
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