内科学
射血分数保留的心力衰竭
医学
射血分数
舒张期
内分泌学
心力衰竭
心脏病学
瘦素
醛固酮
肥胖
血压
作者
Juliana Mira Hernández,Erin Y. Shen,Christopher Y. Ko,Zaynab Hourani,Emily R. Spencer,Daria Smoliarchuk,Julie Bossuyt,Henk Granzier,Donald M. Bers,Bence Hegyi
出处
期刊:Cardiovascular Research
[Oxford University Press]
日期:2024-04-26
被引量:7
摘要
Sex-differences in heart failure with preserved ejection fraction (HFpEF) are important, but key mechanisms involved are incompletely understood. While animal models can inform about sex-dependent cellular and molecular changes, many previous preclinical HFpEF models have failed to recapitulate sex-dependent characteristics of human HFpEF. We tested for sex-differences in HFpEF using a two-hit mouse model (leptin receptor-deficient db/db mice plus aldosterone infusion for 4 weeks; db/db+Aldo).
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