Fonction de l’ARNnc exosomal HEIH dans le carcinome hépatocellulaire associé au virus de l’hépatite B

肝细胞癌 乙型肝炎病毒 医学 乙型肝炎 癌变 长非编码RNA 生物标志物 小RNA 内科学 肿瘤科 病毒 癌症研究 癌症 免疫学 核糖核酸 生物 基因 生物化学
作者
Tao Yu,Huiming Li,Guijia Shen,Qifang Wu
出处
期刊:Annales De Biologie Clinique [John Libbey Eurotext]
卷期号:82 (1): 93-102
标识
DOI:10.1684/abc.2024.1877
摘要

Long non-coding RNA-HEIH (lncRNA-HEIH) is a potential biomarker for patients with hepatocellular carcinoma (HCC), but exosomal lncRNA-HEIH in patients with hepatitis B virus-associated HCC (B-HCC) is unclear. This study aimed to investigate the expression of exosomal lncRNA-HEIH in B-HCC patients and explore its clinical significance. We collected blood samples from 60 B-HCC patients, 60 non-hepatitis virus-associated HCC (N-HCC) patients, and 50 healthy volunteers. Exosomal lncRNA-HEIH levels were measured by real-time PCR and analyzed for their correlation with patient prognosis using Kaplan-Meier analysis. Multivariate COX regression analysis was conducted to identify factors affecting patient outcomes. The effects of lncRNA-HEIH on carcinogenesis were also investigated by constructing a Huh7 cell line stably expressing the hepatitis B virus. In the B-HCC group, there was a positive correlation between hepatitis B virus and exosomal lncRNA-HEIH. The 5-year survival rate of the exosomal lncRNA-HEIH high-expression group was significantly lower than that of the low-expression group in the B-HCC group, but not in the N-HCC group. Exosomal lncRNA-HEIH level was related to the TNM stage, lymph node metastasis and AFP. Exosomal lncRNA-HEIH level was independent risk factors for poor prognosis in B-HCC patients. In Huh7-HBV cells, lncRNA-HEIH level was significantly higher than in control, and the migration capacity of Huh7-HBV cells decreased significantly after down-regulating lncRNA-HEIH. Our findings suggest that exosomal lncRNA-HEIH is abnormally expressed and closely related to poor prognosis in B-HCC patients, indicating its potential as a diagnostic and therapeutic target for HBV-associated HCC.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
李健应助风趣的爆米花采纳,获得10
刚刚
FashionBoy应助无名采纳,获得10
1秒前
超级的丸子完成签到,获得积分10
2秒前
3秒前
隐形曼青应助murry123采纳,获得10
4秒前
ANG完成签到 ,获得积分10
4秒前
5秒前
李嘉欣发布了新的文献求助10
6秒前
6秒前
lascqy完成签到 ,获得积分10
7秒前
wbh发布了新的文献求助10
8秒前
JamesPei应助咚咚咚采纳,获得30
9秒前
小熊熊完成签到,获得积分10
10秒前
Tessa完成签到,获得积分10
10秒前
王心耳完成签到,获得积分10
11秒前
扁舟灬完成签到,获得积分10
11秒前
周婷发布了新的文献求助10
11秒前
11秒前
puff关注了科研通微信公众号
12秒前
12秒前
14秒前
稳重岩完成签到 ,获得积分10
16秒前
loski发布了新的文献求助10
17秒前
步一发布了新的文献求助10
17秒前
18秒前
18秒前
hanleiharry1发布了新的文献求助10
18秒前
18秒前
murry123发布了新的文献求助10
19秒前
痴情的寒云完成签到 ,获得积分10
19秒前
CAOHOU应助张wx_100采纳,获得10
20秒前
21秒前
ppg123应助NightGlow采纳,获得10
22秒前
22秒前
23秒前
emmm发布了新的文献求助10
24秒前
顾矜应助wbh采纳,获得10
25秒前
无辜的夏山完成签到,获得积分10
25秒前
1142722发布了新的文献求助10
26秒前
量子星尘发布了新的文献求助10
27秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989390
求助须知:如何正确求助?哪些是违规求助? 3531487
关于积分的说明 11254109
捐赠科研通 3270153
什么是DOI,文献DOI怎么找? 1804887
邀请新用户注册赠送积分活动 882087
科研通“疑难数据库(出版商)”最低求助积分说明 809174