Traditional Chinese Medicine has great potential as candidate drugs for lung cancer: A review

中医药 医学 药品 肺癌 药理学 科学网 转移 抗药性 传统医学 癌症 肿瘤科 替代医学 内科学 生物 病理 荟萃分析 微生物学
作者
Zhicheng Wei,Jing Chen,Fang Zuo,Julie Guo,Xiaodong Sun,Deming Liu,Conghai Liu
出处
期刊:Journal of Ethnopharmacology [Elsevier BV]
卷期号:300: 115748-115748 被引量:82
标识
DOI:10.1016/j.jep.2022.115748
摘要

With high mortality and morbidity rates, lung cancer (LC) has become one of the major threats to human health. The treatment strategies for LC currently face issues, such as drug resistance and body tolerance. Traditional Chinese medicine (TCM) is characterized by novel pharmacological mechanisms, low toxicity, and limited side effects. TCM includes a substantial number of biologically active ingredients, several of which are effective monomeric agents against LC. An increasing number of researchers are focusing their efforts on the discovery of active anti-cancer ingredients in TCM. In this review, we summarized the anti-LC mechanisms of five types of TCM monomeric compounds. Our goal is to provide research ideas for the identification of new prospective medication candidates for the treatment of LC. We collected reports on the anti-LC effects of TCM monomers from web databases, including PubMed, Science Direct, Web of Science, and Europe PubMed Central. Among the keywords used were “lung cancer,” “traditional Chinese medicine,” “pharmacology,” and their combinations thereof. Then, we systematically summarized the anti-LC efficacy and related mechanisms of TCM monomers. Based on the available literature, this paper reviewed the therapeutic effects and mechanisms of five types of TCM monomers on LC. The characteristics of TCM monomers include the capabilities to suppress the tumor cell cycle, inhibit proliferation, induce apoptosis, promote autophagy, inhibit tumor cell invasion and metastasis, and enhance efficacy or reduce drug resistance when combined with cytotoxic agents and other methods to arrest the progression of LC and prolong the survival of patients. TCM contains numerous flavonoids, alkaloids, terpenoids, polyphenols, and other active compounds that are effective against LC. Given their chemical structure and pharmacological properties, these monomers are suitable as candidate drugs for the treatment of LC.
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