Overcoming Boundaries: Towards the Ambient Aqueous Synthesis of Covalent Organic Frameworks

The synthesis of covalent organic frameworks (COFs) has traditionally been carried out under strict solvothermal and anaerobic conditions. The utilization of organic solvents in such reactions not only carries significant costs but also imposes a great burden on the environment. The fabrication of COFs using alternative synthetic pathways has, therefore, seen rapid development in recent years and much attention has been placed on green and sustainable methods in particular. The synthesis of COFs in purely aqueous media, however, remains challenging due to the delicate nature of the chemical reactions and the crystallization process in water. This mini‐review discusses different synthetic strategies for the construction of crystalline COFs in aqueous media and offers a perspective on the future development of facile COF synthesis in ambient conditions.