Targeting autoimmunity with CD19-CAR T cell therapy: efficacy and seroconversion in diffuse systemic sclerosis and rheumatoid arthritis

Journal Article Accepted manuscript Targeting autoimmunity with CD19-CAR T cell therapy: efficacy and seroconversion in diffuse systemic sclerosis and rheumatoid arthritis Get access Fredrik N Albach, Fredrik N Albach Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Ioanna Minopoulou, Ioanna Minopoulou Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Artur Wilhelm, Artur Wilhelm Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, GermanyDeutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Robert Biesen, Robert Biesen Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Arnd Kleyer, Arnd Kleyer Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Edgar Wiebe, Edgar Wiebe Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Anja Fleischmann, Anja Fleischmann Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Mareike Frick, Mareike Frick Department of Hematology, Oncology and Tumor Immunology, Charité - Universitätsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Frederik Damm, Frederik Damm Department of Hematology, Oncology and Tumor Immunology, Charité - Universitätsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Julia Gogolok, Julia Gogolok Department of Hematology, Oncology and Tumor Immunology, Charité - Universitätsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar ... Show more Sebastian Serve, Sebastian Serve Department of Hematology, Oncology and Tumor Immunology, Charité - Universitätsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Benjamin Nick Locher, Benjamin Nick Locher Department of Hematology, Oncology and Tumor Immunology, Charité - Universitätsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Dominic Borie, Dominic Borie Kyverna Therapeutics, Emeryville, CA, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Vincent Casteleyn, Vincent Casteleyn Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Elise Siegert, Elise Siegert Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, GermanyDeutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Thomas Dörner, Thomas Dörner Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, GermanyDeutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Tobias Alexander, Tobias Alexander Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, GermanyDeutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Christian Furth, Christian Furth Department of Nuclear Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Jan Zernicke, Jan Zernicke Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Kamran Movassaghi, Kamran Movassaghi Department of Hematology, Oncology and Tumor Immunology, Charité - Universitätsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Marie Luise Hütter-Krönke, Marie Luise Hütter-Krönke Department of Hematology, Oncology and Cancer Immunology, Charité - Universitätsmedizin Berlin, Campus Steglitz, Berlin, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Eva Schrezenmeier, Eva Schrezenmeier Deutsches Rheuma-Forschungszentrum Berlin, Berlin, GermanyDepartment of Nephrology, Charité - Universitätsmedizin Berlin, Berlin, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Udo Schneider, Udo Schneider Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Lars Bullinger, Lars Bullinger Department of Hematology, Oncology and Tumor Immunology, Charité - Universitätsmedizin Berlin, Campus Virchow Klinikum, Berlin, GermanyExperimental and Clinical Research Center, Charité - Universitätsmedizin Berlin and Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Gerhard Krönke, Gerhard Krönke Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, GermanyDeutsches Rheuma-Forschungszentrum Berlin, Berlin, GermanyDepartment of Internal Medicine 3, University of Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, GermanyDeutsches Zentrum für Immuntherapie (DZI), University of Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Olaf Penack, Olaf Penack Department of Hematology, Oncology and Tumor Immunology, Charité - Universitätsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar David Simon David Simon Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, GermanyDeutsches Rheuma-Forschungszentrum Berlin, Berlin, GermanyDepartment of Internal Medicine 3, University of Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, GermanyDeutsches Zentrum für Immuntherapie (DZI), University of Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany Corresponding author: Dr David Simon, MD , Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany. [email protected] Search for other works by this author on: Oxford Academic PubMed Google Scholar Rheumatology, keaf077, https://doi.org/10.1093/rheumatology/keaf077 Published: 10 February 2025 Article history Received: 02 November 2024 Revision received: 25 November 2024 Accepted: 11 December 2024 Published: 10 February 2025