已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

DNA Damage Response Alterations Predict for Neoadjuvant Chemotherapy Sensitivity in Muscle-Invasive Bladder Cancer: A Correlative Analysis of the SWOG S1314 Trial

膀胱癌 内科学 医学 危险系数 ERCC2型 肿瘤科 顺铂 比例危险模型 化疗 新辅助治疗 膀胱切除术 癌症 优势比 胃肠病学 病理 DNA修复 置信区间 生物 乳腺癌 基因 核苷酸切除修复 生物化学
作者
Gopa Iyer,Catherine M. Tangen,Michal Sarfaty,Ashley Marie Regazzi,I-Ling Lee,Megan Fong,Woonyoung Choi,Colin P. Dinney,Thomas W. Flaig,Ian M. Thompson,Seth P. Lerner,David J. McConkey,Jonathan E. Rosenberg
出处
期刊:JCO precision oncology [American Society of Clinical Oncology]
卷期号: (8)
标识
DOI:10.1200/po.24.00287
摘要

PURPOSE Alterations in DNA damage response (DDR) genes, including ERCC2 , have been correlated with response to neoadjuvant cisplatin-based chemotherapy (NAC) in patients with muscle-invasive bladder cancer (MIBC). The SWOG 1314 (S1314) trial enrolled patients with MIBC who received one of two NAC regimens followed by radical cystectomy. We examined the prevalence of DDR alterations in NAC responders versus nonresponders and correlated DDR alteration status with response. METHODS Pretreatment tumor specimens from 179 evaluable patients underwent next-generation sequencing (Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets assay). Associations were determined between any or only deleterious alterations within nine predefined DDR genes, or any alterations in ERCC2 , and progression-free survival (PFS) and overall survival using Cox regression, and, in a subset of evaluable patients, pathologic response (complete response, pT0, or downstaging to <pT2) using logistic regression, adjusting for clinical stage and performance status. RESULTS Deleterious DDR alterations were detected in 41 (23%) of 179 patients. Of the 151 patients evaluable for pathologic response, patients with deleterious DDR alterations (n = 39) demonstrated a higher pathologic response rate than those without (odds ratio [OR], 3.24 [95% CI, 1.51 to 6.94]; P = .003). In 24 ERCC2 -mutant patients, the OR for pT0 was 3.33 (95% CI, 1.35 to 8.22; P = .009) and for <pT2 was 2.33 (95% CI, 0.92 to 5.89; P = .073). The association between deleterious DDR alterations and PFS provided an estimate of hazard ratio, 0.54 (95% CI, 0.29 to 1.01; P = .053). CONCLUSION Deleterious DDR alterations were associated with pathologic response following NAC in S1314. Functional validation of ERCC2 and other DDR alterations is underway to help refine such alterations as biomarkers of NAC in patients with bladder cancer.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
2秒前
赵可欣完成签到,获得积分10
2秒前
jiaobuyimi完成签到,获得积分10
3秒前
3秒前
yc发布了新的文献求助10
4秒前
axiao完成签到,获得积分10
5秒前
双黄应助xh采纳,获得10
5秒前
pyt发布了新的文献求助10
6秒前
科研通AI2S应助rylynn采纳,获得10
8秒前
小蘑菇应助科研通管家采纳,获得10
9秒前
9秒前
科研通AI2S应助科研通管家采纳,获得10
9秒前
科研通AI2S应助科研通管家采纳,获得10
9秒前
齐齐巴宾应助pyt采纳,获得10
9秒前
jiaobuyimi发布了新的文献求助10
10秒前
激动的南风完成签到,获得积分10
11秒前
眯缝着眼完成签到,获得积分10
14秒前
16秒前
ggg04228完成签到,获得积分20
16秒前
18秒前
yuaner完成签到,获得积分10
19秒前
20秒前
20秒前
archer01发布了新的文献求助10
23秒前
Akim应助小叶不吃香菜采纳,获得10
25秒前
yuaner发布了新的文献求助10
26秒前
DX完成签到,获得积分10
26秒前
28秒前
源来凯始玺欢你完成签到,获得积分20
30秒前
欢呼妙彤发布了新的文献求助10
33秒前
34秒前
35秒前
38秒前
能干的元龙完成签到 ,获得积分10
38秒前
41秒前
年幼时完成签到 ,获得积分10
41秒前
独特的巨人完成签到,获得积分10
42秒前
shimenwanzhao完成签到 ,获得积分10
43秒前
xAnny发布了新的文献求助10
46秒前
科研进化中完成签到,获得积分10
47秒前
高分求助中
The late Devonian Standard Conodont Zonation 2000
Nickel superalloy market size, share, growth, trends, and forecast 2023-2030 2000
The Lali Section: An Excellent Reference Section for Upper - Devonian in South China 1500
Smart but Scattered: The Revolutionary Executive Skills Approach to Helping Kids Reach Their Potential (第二版) 1000
Very-high-order BVD Schemes Using β-variable THINC Method 830
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 800
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 800
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3248577
求助须知:如何正确求助?哪些是违规求助? 2892044
关于积分的说明 8269473
捐赠科研通 2560089
什么是DOI,文献DOI怎么找? 1388851
科研通“疑难数据库(出版商)”最低求助积分说明 650913
邀请新用户注册赠送积分活动 627798