产热
产热素
脂肪组织
白色脂肪组织
PRDM16
内分泌学
内科学
褐色脂肪组织
褐变
化学
肥胖管理
激活剂(遗传学)
肥胖
生物
生物化学
医学
减肥
受体
作者
Peng Ma,Jie Xiao,Biyu Hou,Ping He,Xinyu Yang,Yisa Wang,Zijing Wang,Tianshu Xu,Xiuying Yang,Xuan Zhu,Shasha Xiang,Li Song,Guanhua Du,Jian Ying,Guifen Qiang
标识
DOI:10.26599/fshw.2022.9250236
摘要
Obesity is a metabolic disorder due to over-accumulation of adipose tissue and ultimately becomes a “disease”. Brown adipose tissue (BAT) thermogenesis and white adipose tissue (WAT) browning emerge as a potential strategy of anti-obesity by dissipating energy as heat. However, drugs based on adipose tissue thermogenesis have not been successfully approved yet. In current study, we found that black tea extract (BTE) obtained by patent-authorized manufacturing process prevented body weight gain as novel thermogenic activator with reduction of adiposity, improvement of adipose distribution, and glucose metabolism improvement in DIO mice. Mechanismly, anti-obesity effect of BTE depends on promoting BAT thermogenesis and WAT browning with upregulation of uncoupling protein 1 (UCP1), especially visceral adipose tissue (VAT) with browning resistance. Specifically, utilizing in silico approach of network pharmacology and molecular docking, we identified carbonic anhydrase 2 (CA2) in nitrogen metabolism as anti-obesity target of BTE and further elucidated that AKT signaling pathway linked CA2 and UCP1. Meanwhile gut microbiota regulation may prompt the CA2-dependent thermogenesis activation. Our findings demonstrated anti-obesity effect of black tea extract as thermogenic activator through CA2-mediated BAT thermogenesis and WAT browning via CA2-AKT-UCP1 signaling pathway, which could be developed as promising anti-obesity agent with good safety and efficacy.
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