Functional and structural brain reorganization in patients with ischemic stroke: a multimodality MRI fusion study

病变 磁共振成像 医学 冲程(发动机) 神经影像学 功能磁共振成像 心脏病学 大脑结构与功能 神经科学 物理医学与康复 放射科 心理学 病理 精神科 机械工程 工程类
作者
Fangyuan Cui,Lei Zhao,Mengxin Lü,Ruoyi Liu,Qiuyi Lv,Dan Lin,Kuangshi Li,Yong Zhang,Yahui Wang,Yue Wang,Liping Wang,Zhongjian Tan,Yiheng Tu,Yihuai Zou
出处
期刊:Cerebral Cortex [Oxford University Press]
卷期号:33 (19): 10453-10462
标识
DOI:10.1093/cercor/bhad295
摘要

Abstract Understanding how structural and functional reorganization occurs is crucial for stroke diagnosis and prognosis. Previous magnetic resonance imaging (MRI) studies focused on the analyses of a single modality and demonstrated abnormalities in both lesion regions and their associated distal regions. However, the relationships of multimodality alterations and their associations with poststroke motor deficits are still unclear. In this study, 71 hemiplegia patients and 41 matched healthy controls (HCs) were recruited and underwent MRI examination at baseline and at 2-week follow-up sessions. A multimodal fusion approach (multimodal canonical correlation analysis + joint independent component analysis), with amplitude of low-frequency fluctuation (ALFF) and gray matter volume (GMV) as features, was used to extract the co-altered patterns of brain structure and function. Then compared the changes in patients’ brain structure and function between baseline and follow-up sessions. Compared with HCs, the brain structure and function of stroke patients decreased synchronously in the local lesions and their associated distal regions. Damage to structure and function in the local lesion regions was associated with motor function. After 2 weeks, ALFF in the local lesion regions was increased, while GMV did not improve. Taken together, the brain structure and function in the local lesions and their associated distal regions were damaged synchronously after ischemic stroke, while during motor recovery, the 2 modalities were changed separately.
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