诱导多能干细胞
医学
微泡
血管生成
再生医学
再生(生物学)
治疗性血管生成
癌症研究
干细胞
生物信息学
病理
细胞生物学
新生血管
胚胎干细胞
小RNA
生物
生物化学
基因
作者
J Zhang,Maoning Shi,Jing Wang,Fei Li,Chenxu Du,Gang Su,Xiaodong Xie,Shi-Weng Li
标识
DOI:10.1177/00033197231213192
摘要
Regeneration after tissue injury is a dynamic and complex process, and angiogenesis is necessary for normal physiological activities and tissue repair. Induced pluripotent stem cells are a new approach in regenerative medicine, which provides good model for the study of difficult-to-obtain human tissues, patient-specific therapy, and tissue repair. As an innovative cell-free therapeutic strategy, the main advantages of the treatment of induced pluripotent stem cells (iPSCs)-derived exosomes are low in tumorigenicity and immunogenicity, which become an important pathway for tissue injury. This review focuses on the mechanism of the angiogenic effect of iPSCs-derived exosomes on wound repair in tissue injury and their potential therapeutic targets, with a view to providing a theoretical basis for the use of iPSCs-derived exosomes in clinical therapy.
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