吡啶
区域选择性
化学
胺气处理
组合化学
戒指(化学)
盐(化学)
三氟甲磺酸
催化作用
有机化学
作者
Haiwen Wang,Michael F. Greaney
标识
DOI:10.1002/anie.202315418
摘要
Abstract An arylation protocol for pyridines is described, via the ring‐opened Zincke intermediate. Treatment of pyridines with triflic anhydride and a secondary amine produces an azahexatriene species, which undergoes regioselective Pd‐catalyzed arylation at the putative C4 position. Recyclization then provides the pyridine products. Alternatively, metal‐free arylation with a diaryliodonium salt is selective for the pyridine meta ‐position, affording a regiodivergent approach to pyridine biaryls from a common intermediate.
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