化学
短梗霉
激进的
支化(高分子化学)
抗氧化剂
无规线圈
水溶液
有机化学
亚甲基
羟基自由基
普鲁兰
氢键
多糖
葡聚糖
清除
立体化学
分子
发酵
圆二色性
作者
Hiroyuki Kono,Hideyuki Hara,Kazumaru Iijima,Shizυo Fujita,Nobuhiro Kondo,Katsuki Hirabayashi,Takuya Isono,Makoto Ogata
标识
DOI:10.1016/j.carbpol.2023.121357
摘要
Aureobasidium pullulans β-(1 → 3, 1 → 6)-glucan (APG) has a high degree of β-(1 → 6)-glucosyl branching and a regular triple helical structure similar to that of schizophyllan. In this study, APG was carboxymethylated to different degrees of substitution (DS = 0.51, 1.0, and 2.0, denoted CMAPG 1-3, respectively) using a heterogeneous reaction. With increasing DS, the triple-helix structure drastically decreased and converted to a random coil structure in CMAPG 3. Further, aqueous solutions of CMAPG changed from pseudoplastic fluids to perfect Newtonian liquids with increasing DS, indicating that the intra- and intermolecular hydrogen bonds had been cleaved by the substituents to form a random coil structure. In addition, APG and CMAPG solutions exhibited scavenging ability against hydroxyl, organic, and sulfate radicals. It was also found that the carboxymethylation of APG drastically enhanced the organic radical scavenging ability. On the basis of the relationship between the DS and radical scavenging ability of the CMAPG samples, we believe hydroxyl and organic radicals were preferably scavenged by the donation of hydrogen atoms from the glucose rings and the methylene moieties of the carboxymethyl groups, respectively. Considering the obtained results, CMAPG and APG are expected to have applications in pharmaceuticals, functional foods, and cosmetics as antioxidant polysaccharides.
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