合成代谢
骨钙素
医学
骨质疏松症
安慰剂
临床试验
成骨细胞
合成代谢剂
内科学
绝经后妇女
内分泌学
随机对照试验
骨重建
药理学
泌尿科
生物信息学
碱性磷酸酶
体外
病理
化学
生物
酶
生物化学
替代医学
作者
Mi Hye Kim,Minkyung Bok,Hyunjung Lim,Woong Mo Yang
出处
期刊:Cells
[MDPI AG]
日期:2023-08-03
卷期号:12 (15): 1992-1992
被引量:4
标识
DOI:10.3390/cells12151992
摘要
The inhibition of bone loss remains a challenge for postmenopausal women, considering the fact that only three anabolic treatments for osteoporosis have been approved by the FDA. This study aimed to investigate the osteogenic capacities of Osteo-F, a newly developed herbal formula, upon integrating network analysis and pre-clinical studies into clinical trials. The network pharmacology analysis showed that a potential mechanism of Osteo-F is closely related to osteoblast differentiation. Consistent with the predicted mechanism, Osteo-F treatment significantly enhanced bone matrix formation and mineralization with collagen expression in osteoblasts. Simultaneously, secreted bone-forming molecules were upregulated by Osteo-F. After the administration of Osteo-F to osteoporotic mice, the femoral BMD and osteocalcin in the serum and bone tissues were significantly improved. Subsequently, a randomized, double-blinded, placebo-controlled clinical trial showed that 253 mg of Osteo-F supplementation for 24 weeks resulted in significant improvements in the Z-score and serum osteocalcin levels of postmenopausal women compared to the placebo, thus indicating bone anabolic efficacy. In the current study, the bone anabolic effect of Osteo-F was determined by activating the differentiation and mineralization of osteoblasts through integrating experiments based on network analysis into clinical trials, with synchronized, reliable evidence, demonstrating that Osteo-F is a novel bone anabolic treatment in postmenopausal women.
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