Ambient air pollution exposure, plasma metabolomic markers, and risk of type 2 diabetes: A prospective cohort study

代谢组学 2型糖尿病 环境卫生 内科学 空气污染 队列研究 环境化学 前瞻性队列研究 队列 医学 环境科学 糖尿病 化学 内分泌学 色谱法 有机化学
作者
Huan Xu,Hao Xu,Jialong Wu,L. Wang,Bing Guo,Weiqi Li,Juying Zhang,Xiong Xiao,Xing Zhao
出处
期刊:Journal of Hazardous Materials [Elsevier BV]
卷期号:463: 132844-132844 被引量:6
标识
DOI:10.1016/j.jhazmat.2023.132844
摘要

Both air pollution (AP) and impaired lipid metabolism contribute to type 2 diabetes (T2D). However, little is known about the detailed associations of AP to lipidomic markers and the specific lipid metabolomic profile that mediates the impact of AP on incident T2D. We aimed to examine the associations between long-term AP exposure, plasma metabolomic markers, and incident T2D, and subsequently determine the lipid metabolomic profile that mediates the relationship between AP and T2D. This prospective study included 82,548 participants from the UK Biobank without a history of T2D at baseline. Baseline plasma samples were analyzed using the nuclear magnetic resonance (NMR) metabolomic platform, which measured 168 metabolomic markers, including lipids, lipoprotein subclasses, and other circulating metabolites. Land Use Regression models were utilized to estimate annual average concentrations of PM2.5 and NO2. The associations among AP, metabolomic markers, and T2D were investigated using multivariable linear regressions and Cox proportional hazards models. Mediation analyses were performed to assess the role of each metabolomic marker in the AP-T2D relationship. Furthermore, principal component (PC) analysis was conducted on 168 metabolomic markers to extract metabolic patterns. These patterns were utilized to determine their associations with AP and T2D, as well as their mediating role in the AP-T2D relationship. We found that long-term AP exposure was associated with some lipid metabolites, including ApoA1, HDL concentration, HDL size, and lipid components within HDL, especially in very large, large, and medium HDL, as well as some other lipids, fatty acids, amino acids, glucose, and glycoprotein acetyls. In pairwise mediation analysis, these metabolites exhibited significant mediation effects in the AP-T2D relationship. We identified six PCS representing distinct metabolic patterns. Long-term exposure to PM2.5 and NO2 showed significantly negative associations with PC2 (characterized by high levels of ApoA1, larger HDL, other lipids, and low levels of larger VLDL). PC2 mediated 12.3% and 10.3% of the associations of PM2.5 and NO2 with incident T2D, respectively. This study revealed the associations of AP with various lipid metabolites. A lipid metabolomic profile characterized by ApoA1 and larger HDL may mediate the association between AP and incident T2D.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
小巧书雪完成签到,获得积分10
2秒前
大大怪将军完成签到,获得积分10
3秒前
哈哈哈完成签到 ,获得积分0
3秒前
小怪完成签到,获得积分10
4秒前
爱吃泡芙完成签到,获得积分10
5秒前
白桃战士完成签到,获得积分10
6秒前
8秒前
qingchenwuhou完成签到 ,获得积分10
8秒前
XXX完成签到,获得积分10
9秒前
锡嘻完成签到 ,获得积分10
9秒前
10秒前
彗星入梦完成签到 ,获得积分10
10秒前
恋恋青葡萄完成签到,获得积分10
10秒前
隐形万言完成签到,获得积分10
12秒前
Time完成签到,获得积分10
12秒前
土木研学僧完成签到,获得积分10
13秒前
yjy完成签到 ,获得积分10
13秒前
A溶大美噶完成签到,获得积分10
13秒前
yar应助萨尔莫斯采纳,获得10
14秒前
Will发布了新的文献求助10
14秒前
美好的鹏笑完成签到,获得积分10
16秒前
啦啦啦啦啦完成签到,获得积分10
16秒前
LYegoist完成签到,获得积分10
18秒前
可爱的小丸子完成签到,获得积分10
18秒前
一川烟叶完成签到,获得积分10
20秒前
20秒前
23秒前
iFan完成签到 ,获得积分10
23秒前
萨尔莫斯完成签到,获得积分10
23秒前
合适靖儿完成签到 ,获得积分10
25秒前
林林林完成签到,获得积分10
26秒前
斯琪欣完成签到,获得积分10
27秒前
28秒前
MQQ完成签到 ,获得积分10
28秒前
meng发布了新的文献求助10
28秒前
29秒前
zxc167完成签到,获得积分10
29秒前
研友_nVWP2Z完成签到 ,获得积分10
31秒前
俭朴的半雪完成签到 ,获得积分10
32秒前
大橙子发布了新的文献求助10
33秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038201
求助须知:如何正确求助?哪些是违规求助? 3575940
关于积分的说明 11373987
捐赠科研通 3305747
什么是DOI,文献DOI怎么找? 1819274
邀请新用户注册赠送积分活动 892662
科研通“疑难数据库(出版商)”最低求助积分说明 815022