Integration and dosimetric validation of a dynamic collimation system for pencil beam scanning proton therapy

束流扫描 质子疗法 准直光 蒙特卡罗方法 电离室 核医学 放射治疗计划 铅笔(光学) 质子 梁(结构) 材料科学 光学 生物医学工程 物理 电离 激光器 放射治疗 医学 数学 核物理学 外科 统计 离子 量子力学
作者
Nicholas P Nelson,Wesley S. Culberson,Daniel E. Hyer,Theodore Geoghegan,Kaustubh Patwardhan,Blake Smith,Ryan T. Flynn,Alonso N. Gutiérrez,T Boland,P Hill
出处
期刊:Biomedical Physics & Engineering Express [IOP Publishing]
卷期号:9 (6): 065024-065024
标识
DOI:10.1088/2057-1976/ad02ff
摘要

Objective.To integrate a Dynamic Collimation System (DCS) into a pencil beam scanning (PBS) proton therapy system and validate its dosimetric impact.Approach.Uncollimated and collimated treatment fields were developed for clinically relevant targets using an in-house treatment plan optimizer and an experimentally validated Monte Carlo model of the DCS and IBA dedicated nozzle (DN) system. The dose reduction induced by the DCS was quantified by calculating the mean dose in 10- and 30-mm two-dimensional rinds surrounding the target. A select number of plans were then used to experimentally validate the mechanical integration of the DCS and beam scanning controller system through measurements with the MatriXX-PT ionization chamber array and EBT3 film. Absolute doses were verified at the central axis at various depths using the IBA MatriXX-PT and PPC05 ionization chamber.Main results.Simulations demonstrated a maximum mean dose reduction of 12% for the 10 mm rind region and 45% for the 30 mm rind region when utilizing the DCS. Excellent agreement was observed between Monte Carlo simulations, EBT3 film, and MatriXX-PT measurements, with gamma pass rates exceeding 94.9% for all tested plans at the 3%/2 mm criterion. Absolute central axis doses showed an average verification difference of 1.4% between Monte Carlo and MatriXX-PT/PPC05 measurements.Significance.We have successfully dosimetrically validated the delivery of dynamically collimated proton therapy for clinically relevant delivery patterns and dose distributions with the DCS. Monte Carlo simulations were employed to assess dose reductions and treatment planning considerations associated with the DCS.
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