降级(电信)
生物相容性
聚酯纤维
弹性体
柠檬酸
生物降解
化学
聚合物
化学工程
材料科学
生物医学工程
核化学
高分子化学
生物化学
有机化学
医学
电信
计算机科学
工程类
作者
Lu Wan,Liangliang Lu,Xuejiao Liang,Zhichang Liu,Xinxin Huang,Ruichun Du,Qiong Luo,Qiang Xu,Qiuhong Zhang,Xudong Jia
出处
期刊:Biomacromolecules
[American Chemical Society]
日期:2023-08-16
卷期号:24 (9): 4123-4137
被引量:3
标识
DOI:10.1021/acs.biomac.3c00479
摘要
Citrate-based polymers are commonly used to create biodegradable implants. In an era of personalized medicine, it is highly desired that the degradation rates of citrate-based implants can be artificially regulated as required during clinical applications. Unfortunately, current citrate-based polymers only undergo passive degradation, which follows a specific degradation profile. This presents a considerable challenge for the use of citrate-based implants. To address this, a novel citrate-based polyester elastomer (POCSS) with artificially regulatable degradation rate is developed by incorporating disulfide bonds (S-S) into the backbone chains of the crosslinking network of poly(octamethylene citrate) (POC). This POCSS exhibits excellent and tunable mechanical properties, notable antibacterial properties, good biocompatibility, and low biotoxicity of its degradation products. The degradation rate of the POCSS can be regulated by breaking the S-S in its crosslinking network using glutathione (GSH). After a period of subcutaneous implantation of POCSS scaffolds in mice, the degradation rate eventually increased by 2.46 times through the subcutaneous administration of GSH. Notably, we observed no significant adverse effects on its surrounding tissues, the balance of the physiological environment, major organs, and the health status of the mice during degradation.
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