亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Ambient fine particulate matter exposures and human early placental inflammation

滞后 分布滞后 怀孕 医学 混淆 内科学 内分泌学 生理学 生物 数学 计算机网络 计算机科学 计量经济学 遗传学
作者
Chen Gong,Mengyu Chu,Junnan Yang,Xian Gong,Bin Han,Li Chen,Bai Zhang,Jianmei Wang,Yujuan Zhang
出处
期刊:Environmental Pollution [Elsevier]
卷期号:315: 120446-120446 被引量:3
标识
DOI:10.1016/j.envpol.2022.120446
摘要

The effect of fine particulate matter (PM2.5) on human early maternal-fetal interface is unknown. We explored the association between maternal exposure to ambient PM2.5 and inflammation in placental villus of 114 women with clinically recognized early pregnancy loss (CREPL) and 114 women with normal early pregnancy (NEP). Temporally-adjusted land use regression models were used to estimate maternal daily PM2.5 exposure during pregnancy. Villus interleukin-1beta (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) were measured using multiplex cytokines detection platform. Single-day lag effect of PM2.5 exposure within ten days before early placental villus collection was estimated using multivariable linear regression model. Distributed lag and net cumulative effects of PM2.5 exposures within ten and 30 days before villus collection, as well as five single weeks during the periovulatory period, were estimated using distributed lag non-linear models. In all 228 subjects, after adjusting for group (CREPL or NEP), temporal confounders, and demographic characteristics, both single-day and distributed lag effects of PM2.5 exposure at lag 8 significantly increased villus IL-6; distributed lag effects of PM2.5 exposure in the first and second weeks before ovulation increased IL-1β, and PM2.5 exposure in the third week after ovulation increased IL-6 and TNF-α. In CREPL, single-day lag effect significantly increased IL-1β (at lag 1), IL-6 (at lag 8), and TNF-α (at lag 5); distributed lag effect increased IL-6 (at lag 4-lag 8) and TNF-α (at lag 4-lag 6); and cumulative effect within ten days before villus collection increased IL-6. There was no statistically significant cumulative effect in NEP. In summary, maternal PM2.5 exposure was associated with placental inflammation in human early pregnancy, particularly with increased villus IL-6 in CREPL. Whether maternal-fetal interface inflammation related to PM2.5 exposure during the periovulatory period or later contributes to CREPL or other adverse pregnancy outcomes requires further study.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
seayoa发布了新的文献求助10
31秒前
柠檬完成签到,获得积分10
34秒前
Raunio完成签到,获得积分10
35秒前
学术小白完成签到,获得积分10
35秒前
seayoa完成签到,获得积分10
47秒前
siuu发布了新的文献求助10
49秒前
乐乐应助lauwsum采纳,获得10
50秒前
52秒前
碧蓝太英发布了新的文献求助10
57秒前
59秒前
lauwsum发布了新的文献求助10
1分钟前
Leo完成签到 ,获得积分10
1分钟前
1分钟前
Zz完成签到 ,获得积分10
1分钟前
feiCheung完成签到 ,获得积分10
1分钟前
崔cui完成签到 ,获得积分10
1分钟前
可爱的函函应助碧蓝太英采纳,获得10
1分钟前
yangjinru完成签到 ,获得积分10
2分钟前
2分钟前
zqq完成签到,获得积分0
2分钟前
Ray羽曦~发布了新的文献求助10
2分钟前
莫星晨完成签到,获得积分10
2分钟前
66完成签到,获得积分10
2分钟前
Hello应助奋斗的杰采纳,获得30
2分钟前
3分钟前
现代青枫应助科研通管家采纳,获得10
3分钟前
3分钟前
zengtx1发布了新的文献求助10
3分钟前
siuu完成签到,获得积分20
3分钟前
zengtx1完成签到,获得积分10
3分钟前
LLL完成签到,获得积分10
3分钟前
xiaofei666应助siuu采纳,获得50
4分钟前
小二郎应助阿塔潘采纳,获得10
4分钟前
肉丸完成签到 ,获得积分10
4分钟前
李志全完成签到 ,获得积分10
5分钟前
5分钟前
andrele应助科研通管家采纳,获得10
5分钟前
5分钟前
黎少俊发布了新的文献求助10
5分钟前
黎少俊完成签到,获得积分10
5分钟前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Evolution 3rd edition 1500
保险藏宝图 1000
Lire en communiste 1000
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 700
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 700
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3186712
求助须知:如何正确求助?哪些是违规求助? 2836903
关于积分的说明 8011874
捐赠科研通 2499260
什么是DOI,文献DOI怎么找? 1334253
科研通“疑难数据库(出版商)”最低求助积分说明 637135
邀请新用户注册赠送积分活动 605032