Ambient fine particulate matter exposures and human early placental inflammation

滞后 分布滞后 怀孕 医学 混淆 内科学 内分泌学 生理学 生物 数学 计算机网络 计算机科学 计量经济学 遗传学
作者
Chen Gong,Mengyu Chu,Junnan Yang,Xian Gong,Bin Han,Li Chen,Bai Zhang,Jianmei Wang,Yujuan Zhang
出处
期刊:Environmental Pollution [Elsevier]
卷期号:315: 120446-120446 被引量:3
标识
DOI:10.1016/j.envpol.2022.120446
摘要

The effect of fine particulate matter (PM2.5) on human early maternal-fetal interface is unknown. We explored the association between maternal exposure to ambient PM2.5 and inflammation in placental villus of 114 women with clinically recognized early pregnancy loss (CREPL) and 114 women with normal early pregnancy (NEP). Temporally-adjusted land use regression models were used to estimate maternal daily PM2.5 exposure during pregnancy. Villus interleukin-1beta (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) were measured using multiplex cytokines detection platform. Single-day lag effect of PM2.5 exposure within ten days before early placental villus collection was estimated using multivariable linear regression model. Distributed lag and net cumulative effects of PM2.5 exposures within ten and 30 days before villus collection, as well as five single weeks during the periovulatory period, were estimated using distributed lag non-linear models. In all 228 subjects, after adjusting for group (CREPL or NEP), temporal confounders, and demographic characteristics, both single-day and distributed lag effects of PM2.5 exposure at lag 8 significantly increased villus IL-6; distributed lag effects of PM2.5 exposure in the first and second weeks before ovulation increased IL-1β, and PM2.5 exposure in the third week after ovulation increased IL-6 and TNF-α. In CREPL, single-day lag effect significantly increased IL-1β (at lag 1), IL-6 (at lag 8), and TNF-α (at lag 5); distributed lag effect increased IL-6 (at lag 4-lag 8) and TNF-α (at lag 4-lag 6); and cumulative effect within ten days before villus collection increased IL-6. There was no statistically significant cumulative effect in NEP. In summary, maternal PM2.5 exposure was associated with placental inflammation in human early pregnancy, particularly with increased villus IL-6 in CREPL. Whether maternal-fetal interface inflammation related to PM2.5 exposure during the periovulatory period or later contributes to CREPL or other adverse pregnancy outcomes requires further study.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
yuyuyuyuyuyuyu完成签到,获得积分10
刚刚
研友_VZG7GZ应助ll采纳,获得10
刚刚
1秒前
li发布了新的文献求助10
2秒前
2秒前
JamesPei应助lumina采纳,获得10
3秒前
今后应助猴儿采纳,获得10
4秒前
不负发布了新的文献求助10
4秒前
共享精神应助小龙儿采纳,获得10
4秒前
5秒前
星离zjp发布了新的文献求助10
5秒前
卜颖滨发布了新的文献求助30
6秒前
我是老大应助Good采纳,获得10
6秒前
6秒前
7秒前
8秒前
在水一方应助ylq采纳,获得10
8秒前
领导范儿应助Smilegate采纳,获得10
8秒前
lili完成签到,获得积分10
9秒前
wjl完成签到,获得积分10
10秒前
10秒前
10秒前
风车发布了新的文献求助10
10秒前
LXX发布了新的文献求助10
11秒前
11秒前
FashionBoy应助sxyyy采纳,获得10
11秒前
归途发布了新的文献求助30
12秒前
myl完成签到,获得积分10
12秒前
华仔应助哈比采纳,获得10
12秒前
1282941496发布了新的文献求助10
12秒前
lele完成签到,获得积分10
12秒前
13秒前
柳叶刀的终极传人完成签到,获得积分10
13秒前
奋斗康乃馨完成签到 ,获得积分10
13秒前
14秒前
学术rookie发布了新的文献求助10
14秒前
14秒前
斌斌发布了新的文献求助10
15秒前
Pacer发布了新的文献求助10
16秒前
ll发布了新的文献求助10
16秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Evolution 3rd edition 1500
保险藏宝图 1000
Lire en communiste 1000
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 700
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 700
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3185214
求助须知:如何正确求助?哪些是违规求助? 2835543
关于积分的说明 8005317
捐赠科研通 2497979
什么是DOI,文献DOI怎么找? 1333224
科研通“疑难数据库(出版商)”最低求助积分说明 636803
邀请新用户注册赠送积分活动 604404