Ambient fine particulate matter exposures and human early placental inflammation

滞后 分布滞后 怀孕 医学 混淆 内科学 内分泌学 生理学 生物 数学 计算机网络 计算机科学 计量经济学 遗传学
作者
Chen Gong,Mengyu Chu,Junnan Yang,Xian Gong,Bin Han,Li Chen,Bai Zhang,Jianmei Wang,Yujuan Zhang
出处
期刊:Environmental Pollution [Elsevier]
卷期号:315: 120446-120446 被引量:3
标识
DOI:10.1016/j.envpol.2022.120446
摘要

The effect of fine particulate matter (PM2.5) on human early maternal-fetal interface is unknown. We explored the association between maternal exposure to ambient PM2.5 and inflammation in placental villus of 114 women with clinically recognized early pregnancy loss (CREPL) and 114 women with normal early pregnancy (NEP). Temporally-adjusted land use regression models were used to estimate maternal daily PM2.5 exposure during pregnancy. Villus interleukin-1beta (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) were measured using multiplex cytokines detection platform. Single-day lag effect of PM2.5 exposure within ten days before early placental villus collection was estimated using multivariable linear regression model. Distributed lag and net cumulative effects of PM2.5 exposures within ten and 30 days before villus collection, as well as five single weeks during the periovulatory period, were estimated using distributed lag non-linear models. In all 228 subjects, after adjusting for group (CREPL or NEP), temporal confounders, and demographic characteristics, both single-day and distributed lag effects of PM2.5 exposure at lag 8 significantly increased villus IL-6; distributed lag effects of PM2.5 exposure in the first and second weeks before ovulation increased IL-1β, and PM2.5 exposure in the third week after ovulation increased IL-6 and TNF-α. In CREPL, single-day lag effect significantly increased IL-1β (at lag 1), IL-6 (at lag 8), and TNF-α (at lag 5); distributed lag effect increased IL-6 (at lag 4-lag 8) and TNF-α (at lag 4-lag 6); and cumulative effect within ten days before villus collection increased IL-6. There was no statistically significant cumulative effect in NEP. In summary, maternal PM2.5 exposure was associated with placental inflammation in human early pregnancy, particularly with increased villus IL-6 in CREPL. Whether maternal-fetal interface inflammation related to PM2.5 exposure during the periovulatory period or later contributes to CREPL or other adverse pregnancy outcomes requires further study.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
星孜完成签到,获得积分20
刚刚
狂野思卉发布了新的文献求助10
1秒前
孤城发布了新的文献求助10
1秒前
小先完成签到,获得积分10
2秒前
愤怒的紫发布了新的文献求助10
2秒前
小鱼发布了新的文献求助10
2秒前
啊湫超爱学习完成签到,获得积分10
3秒前
烟花应助六味地黄丸采纳,获得10
3秒前
4秒前
酷波er应助dd采纳,获得10
5秒前
tuo zhang完成签到,获得积分10
6秒前
7秒前
郁金香发布了新的文献求助10
7秒前
芯茶完成签到 ,获得积分10
8秒前
张小凡发布了新的文献求助10
8秒前
清爽小白菜完成签到,获得积分10
8秒前
Hello应助ABS采纳,获得10
9秒前
kk发布了新的文献求助30
9秒前
JamesPei应助luca采纳,获得10
10秒前
小二郎应助小奋斗采纳,获得10
11秒前
11秒前
11秒前
11秒前
11秒前
bkagyin应助小鱼采纳,获得10
12秒前
vivia完成签到 ,获得积分10
12秒前
跳跃的乌龟完成签到,获得积分20
12秒前
HAHAHA发布了新的文献求助10
13秒前
程单梦发布了新的文献求助10
13秒前
郁金香完成签到,获得积分10
14秒前
顾矜应助sweetheart采纳,获得10
14秒前
脑洞疼应助害羞小土豆采纳,获得20
14秒前
14秒前
16秒前
研友_850dqZ完成签到,获得积分20
16秒前
ninomae给ninomae的求助进行了留言
17秒前
CHC发布了新的文献求助10
17秒前
HAHAHA完成签到,获得积分10
17秒前
17秒前
星孜发布了新的文献求助10
18秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Write Like a Chemist: A Guide and Resource (第二版) 600
Mixed-anion Compounds 600
A new species of Velataspis (Hemiptera Coccoidea Diaspididae) from tea in Assam 500
Earth System Geophysics 500
Aspects of Babylonian celestial divination: the lunar eclipse tablets of Enūma Anu Enlil 500
Geochemistry, 2nd Edition 地球化学经典教科书第二版 401
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3200070
求助须知:如何正确求助?哪些是违规求助? 2849818
关于积分的说明 8070095
捐赠科研通 2513658
什么是DOI,文献DOI怎么找? 1346482
科研通“疑难数据库(出版商)”最低求助积分说明 640227
邀请新用户注册赠送积分活动 610102