Ambient fine particulate matter exposures and human early placental inflammation

滞后 分布滞后 怀孕 医学 混淆 内科学 内分泌学 生理学 生物 数学 计算机网络 计算机科学 计量经济学 遗传学
作者
Chen Gong,Mengyu Chu,Junnan Yang,Xian Gong,Bin Han,Li Chen,Bai Zhang,Jianmei Wang,Yujuan Zhang
出处
期刊:Environmental Pollution [Elsevier]
卷期号:315: 120446-120446 被引量:3
标识
DOI:10.1016/j.envpol.2022.120446
摘要

The effect of fine particulate matter (PM2.5) on human early maternal-fetal interface is unknown. We explored the association between maternal exposure to ambient PM2.5 and inflammation in placental villus of 114 women with clinically recognized early pregnancy loss (CREPL) and 114 women with normal early pregnancy (NEP). Temporally-adjusted land use regression models were used to estimate maternal daily PM2.5 exposure during pregnancy. Villus interleukin-1beta (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) were measured using multiplex cytokines detection platform. Single-day lag effect of PM2.5 exposure within ten days before early placental villus collection was estimated using multivariable linear regression model. Distributed lag and net cumulative effects of PM2.5 exposures within ten and 30 days before villus collection, as well as five single weeks during the periovulatory period, were estimated using distributed lag non-linear models. In all 228 subjects, after adjusting for group (CREPL or NEP), temporal confounders, and demographic characteristics, both single-day and distributed lag effects of PM2.5 exposure at lag 8 significantly increased villus IL-6; distributed lag effects of PM2.5 exposure in the first and second weeks before ovulation increased IL-1β, and PM2.5 exposure in the third week after ovulation increased IL-6 and TNF-α. In CREPL, single-day lag effect significantly increased IL-1β (at lag 1), IL-6 (at lag 8), and TNF-α (at lag 5); distributed lag effect increased IL-6 (at lag 4-lag 8) and TNF-α (at lag 4-lag 6); and cumulative effect within ten days before villus collection increased IL-6. There was no statistically significant cumulative effect in NEP. In summary, maternal PM2.5 exposure was associated with placental inflammation in human early pregnancy, particularly with increased villus IL-6 in CREPL. Whether maternal-fetal interface inflammation related to PM2.5 exposure during the periovulatory period or later contributes to CREPL or other adverse pregnancy outcomes requires further study.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
852应助莫愁采纳,获得10
3秒前
如约发布了新的文献求助20
4秒前
夏沫完成签到,获得积分10
5秒前
7秒前
8秒前
dapao发布了新的文献求助10
9秒前
邓邓完成签到,获得积分10
12秒前
14秒前
我爱科研完成签到 ,获得积分10
14秒前
15秒前
dapao完成签到,获得积分10
15秒前
16秒前
上官若男应助学业顺利采纳,获得10
18秒前
sfef完成签到,获得积分10
18秒前
充电宝应助wangsikui采纳,获得10
18秒前
20秒前
20秒前
慕青应助杨枝甘露樱桃采纳,获得10
21秒前
不配.应助杨枝甘露樱桃采纳,获得10
21秒前
思源应助伍仨仨采纳,获得10
22秒前
莫愁发布了新的文献求助10
24秒前
小油条完成签到,获得积分10
24秒前
27秒前
shihui发布了新的文献求助10
30秒前
CipherSage应助小水滴采纳,获得10
31秒前
研友_nvGY4Z发布了新的文献求助10
32秒前
Akim应助听话的大碗采纳,获得10
32秒前
小骁同学完成签到,获得积分10
36秒前
40秒前
41秒前
设计师做做人完成签到,获得积分10
42秒前
hexiaoxiao完成签到,获得积分10
43秒前
nczpf2010完成签到,获得积分10
45秒前
MISHA发布了新的文献求助10
45秒前
王木木完成签到,获得积分10
47秒前
xxx发布了新的文献求助10
48秒前
清爽的向南完成签到,获得积分10
49秒前
小水滴完成签到,获得积分10
49秒前
51秒前
51秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Evolution 3rd edition 1500
保险藏宝图 1000
Lire en communiste 1000
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 700
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 700
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3186379
求助须知:如何正确求助?哪些是违规求助? 2836732
关于积分的说明 8010637
捐赠科研通 2499055
什么是DOI,文献DOI怎么找? 1334061
科研通“疑难数据库(出版商)”最低求助积分说明 637023
邀请新用户注册赠送积分活动 604964