Ambient fine particulate matter exposures and human early placental inflammation

滞后 分布滞后 怀孕 医学 混淆 内科学 内分泌学 生理学 生物 数学 计算机网络 计算机科学 计量经济学 遗传学
作者
Chen Gong,Mengyu Chu,Junnan Yang,Xian Gong,Bin Han,Li Chen,Bai Zhang,Jianmei Wang,Yujuan Zhang
出处
期刊:Environmental Pollution [Elsevier]
卷期号:315: 120446-120446 被引量:3
标识
DOI:10.1016/j.envpol.2022.120446
摘要

The effect of fine particulate matter (PM2.5) on human early maternal-fetal interface is unknown. We explored the association between maternal exposure to ambient PM2.5 and inflammation in placental villus of 114 women with clinically recognized early pregnancy loss (CREPL) and 114 women with normal early pregnancy (NEP). Temporally-adjusted land use regression models were used to estimate maternal daily PM2.5 exposure during pregnancy. Villus interleukin-1beta (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) were measured using multiplex cytokines detection platform. Single-day lag effect of PM2.5 exposure within ten days before early placental villus collection was estimated using multivariable linear regression model. Distributed lag and net cumulative effects of PM2.5 exposures within ten and 30 days before villus collection, as well as five single weeks during the periovulatory period, were estimated using distributed lag non-linear models. In all 228 subjects, after adjusting for group (CREPL or NEP), temporal confounders, and demographic characteristics, both single-day and distributed lag effects of PM2.5 exposure at lag 8 significantly increased villus IL-6; distributed lag effects of PM2.5 exposure in the first and second weeks before ovulation increased IL-1β, and PM2.5 exposure in the third week after ovulation increased IL-6 and TNF-α. In CREPL, single-day lag effect significantly increased IL-1β (at lag 1), IL-6 (at lag 8), and TNF-α (at lag 5); distributed lag effect increased IL-6 (at lag 4-lag 8) and TNF-α (at lag 4-lag 6); and cumulative effect within ten days before villus collection increased IL-6. There was no statistically significant cumulative effect in NEP. In summary, maternal PM2.5 exposure was associated with placental inflammation in human early pregnancy, particularly with increased villus IL-6 in CREPL. Whether maternal-fetal interface inflammation related to PM2.5 exposure during the periovulatory period or later contributes to CREPL or other adverse pregnancy outcomes requires further study.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
高海龙完成签到 ,获得积分10
刚刚
misa完成签到 ,获得积分10
2秒前
3秒前
领导范儿应助atobezy采纳,获得20
9秒前
我爱康康文献完成签到 ,获得积分10
12秒前
我是老大应助Ivy采纳,获得10
12秒前
daydayup完成签到 ,获得积分10
14秒前
21秒前
344061512完成签到 ,获得积分10
24秒前
atobezy发布了新的文献求助20
24秒前
651完成签到 ,获得积分10
33秒前
37秒前
萧水白完成签到,获得积分10
40秒前
Snow完成签到 ,获得积分10
41秒前
sutychen发布了新的文献求助10
42秒前
缘分完成签到,获得积分10
47秒前
50秒前
Jasper应助科研通管家采纳,获得10
1分钟前
Casey完成签到 ,获得积分10
1分钟前
小叙完成签到 ,获得积分10
1分钟前
1分钟前
简单的冬瓜完成签到,获得积分10
1分钟前
糖豆子发布了新的文献求助10
1分钟前
1分钟前
zhangzhangzhang完成签到 ,获得积分10
1分钟前
Ivy发布了新的文献求助10
1分钟前
汉堡包应助atobezy采纳,获得10
1分钟前
研友_ZA2B68完成签到,获得积分10
1分钟前
Ivy完成签到,获得积分10
1分钟前
fang完成签到,获得积分10
1分钟前
勤劳的颤完成签到 ,获得积分10
1分钟前
萝卜丁完成签到 ,获得积分10
1分钟前
朴实的面包完成签到 ,获得积分10
1分钟前
chenying完成签到 ,获得积分0
1分钟前
J陆lululu完成签到 ,获得积分10
1分钟前
丝丢皮得完成签到 ,获得积分10
2分钟前
小香香完成签到 ,获得积分10
2分钟前
兔兔完成签到 ,获得积分10
2分钟前
乐乐完成签到,获得积分10
2分钟前
蓝兰发布了新的文献求助10
2分钟前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Evolution 3rd edition 1500
保险藏宝图 1000
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 700
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 700
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3186894
求助须知:如何正确求助?哪些是违规求助? 2836960
关于积分的说明 8011996
捐赠科研通 2499375
什么是DOI,文献DOI怎么找? 1334354
科研通“疑难数据库(出版商)”最低求助积分说明 637170
邀请新用户注册赠送积分活动 605071