Direct Assembly of Polysubstituted Furans with Dimethyl Sulfoxide as a Multipurpose Precursor via β‐C(sp3)−H Functionalization of Saturated Ketones

Abstract An I 2 /K 2 S 2 O 8 mediated multiple β‐C( sp 3 )−H functionalization reaction for the construction of polysubstituted furans has been established from readily available ethyl ketones and dimethyl sulfoxide. This transformation features dimethyl sulfoxide as a multipurpose precursor, acting as the precursor of the oxygen, methyl, and sulfur methyl units. Six new chemical bonds, involving two C−C, two C−O, and one C−S bonds were formed sequentially during the intermolecular oxidative annulation process. magnified image