化学
光催化
小学(天文学)
叔胺
纳米技术
有机化学
催化作用
物理
材料科学
天文
作者
Xianzhou Zheng,Weiming Yuan
标识
DOI:10.1002/ejoc.202400350
摘要
Abstract α ‐Tertiary primary amines ( α ‐TPAs) bearing a fully substituted carbon center adjacent to the N ‐unsubstituted amino group (−NH 2 ) exhibit unique biochemical and physicochemical activities. While due to the sterically congested structure and strong nucleophilic and alkaline natures of these primary amine compounds, their facile synthesis remains an inherent challenge. Traditional methods commonly rely on tedious N ‐protection/deprotection operations and highly reactive organometallic reagents, thus leading to poor atom and step‐economy and limited functional group compatibility. Modern photoredox catalysis offers a robust tool to prepare such structurally unique and synthetically valuable amine architectures via a radical pathway under extremely mild conditions. In this review, the recent progress in photocatalytic synthesis of α ‐TPAs is systematically reviewed, and the reaction scope, limitations, and mechanisms for the reactions are discussed.
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