Multifunctional Metal–Organic Frameworks Driven Three-Dimensional Folded Paper-Based Microfluidic Analysis Device for Chlorpyrifos Detection

纳米探针 微流控 双金属 荧光 适体 纳米技术 纳米材料 材料科学 化学 纳米颗粒 生物 遗传学 量子力学 物理 复合材料
作者
Shuangshuang Liu,Mingming Zhang,Quansheng Chen,Qin Ouyang
出处
期刊:Journal of Agricultural and Food Chemistry [American Chemical Society]
卷期号:72 (25): 14375-14385 被引量:7
标识
DOI:10.1021/acs.jafc.4c02875
摘要

Chlorpyrifos (CPF) residues in food pose a serious threat to ecosystems and human health. Herein, we propose a three-dimensional folded paper-based microfluidic analysis device (3D-μPAD) based on multifunctional metal–organic frameworks, which can achieve rapid quantitative detection of CPF by fluorescence-colorimetric dual-mode readout. Upconversion nanomaterials were first coupled with a bimetal organic framework possessing peroxidase activity to create a fluorescence-quenched nanoprobe. After that, the 3D-μPAD was finished by loading the nanoprobe onto the paper-based detection zone and spraying it with a color-developing solution. With CPF present, the fluorescence intensity of the detection zone gradually recovers, the color changes from colorless to blue. This showed a good linear relationship with the concentration of CPF, and the limits of detection were 0.028 (fluorescence) and 0.043 (colorimetric) ng/mL, respectively. Moreover, the 3D-μPAD was well applied in detecting real samples with no significant difference compared with the high-performance liquid chromatography method. We believe it has huge potential for application in the on-site detection of food hazardous substance residues.
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