宫颈癌
癌症
癌变
疾病
特质
生物
基因型
接种疫苗
人乳头瘤病毒疫苗
病毒学
人乳头瘤病毒
医学
HPV感染
免疫学
遗传学
内科学
基因
计算机科学
程序设计语言
作者
Mariano A. Molina,Renske D.M. Steenbergen,Anna Elisabeth Pumpe,Angelique N. Kenyon,Willem J. G. Melchers
标识
DOI:10.1016/j.molmed.2024.05.009
摘要
Countless efforts have been made to eradicate cervical cancer worldwide, including improving disease screening and human papillomavirus (HPV) vaccination programs. Nevertheless, cervical cancer still claims the lives of more than 300 000 women every year. Persistent infections with high-risk HPV genotypes 16 and 18 are the main cause of cancer and may result in HPV integration into the host genome. The central dogma is that HPV integration is an important step in oncogenesis, but in fact, it impedes the virus from replicating and spreading. HPV causing cervical cancer can therefore be perceived as a failed evolutionary viral trait. Here we outline the occurrence and mechanisms of HPV integration and how this process results in oncogenic transformation.
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