自噬
脂质过氧化
GPX4
黄斑变性
程序性细胞死亡
视网膜母细胞瘤
氧化应激
活性氧
细胞生物学
糖尿病性视网膜病变
坏死性下垂
上睑下垂
医学
癌症研究
生物信息学
细胞凋亡
生物
眼科
糖尿病
内科学
遗传学
内分泌学
过氧化氢酶
谷胱甘肽过氧化物酶
基因
作者
Yaqi Yang,Yusong Lin,Guochen Zhang,Bo Wang,Wei Zheng,Lidong Wei
标识
DOI:10.3389/fimmu.2024.1440309
摘要
Ferroptosis, a new type of programmed cell death proposed in recent years, is characterized mainly by reactive oxygen species and iron-mediated lipid peroxidation and differs from programmed cell death, such as apoptosis, necrosis, and autophagy. Ferroptosis is associated with a variety of physiological and pathophysiological processes. Recent studies have shown that ferroptosis can aggravate or reduce the occurrence and development of diseases by targeting metabolic pathways and signaling pathways in tumors, ischemic organ damage, and other degenerative diseases related to lipid peroxidation. Increasing evidence suggests that ferroptosis is closely linked to the onset and progression of various ophthalmic conditions, including corneal injury, glaucoma, age-related macular degeneration, diabetic retinopathy, retinal detachment, and retinoblastoma. Our review of the current research on ferroptosis in ophthalmic diseases reveals significant advancements in our understanding of the pathogenesis, aetiology, and treatment of these conditions.
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