亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Extrahepatic Malignancies and Antiviral Drugs for Chronic Hepatitis B: A Nationwide Cohort Study

医学 恩替卡韦 内科学 危险系数 队列 倾向得分匹配 置信区间 入射(几何) 比例危险模型 恶性肿瘤 混淆 慢性肝炎 胃肠病学 免疫学 拉米夫定 病毒 物理 光学
作者
Moon Haeng Hur,Dong Hyeon Lee,Jeong Hoon Lee,Misook Kim,Jeayeon Park,Hyun‐Jae Shin,Sung Won Chung,Hee Jin Cho,Min Kyung Park,Heejoon Jang,Yun Bin Lee,Su Jong Yu,Sang Hyub Lee,Yong Jin Jung,Yoon Jun Kim,Jung‐Hwan Yoon
出处
期刊:Clinical and molecular hepatology [Korean Association for the Study of the Liver]
标识
DOI:10.3350/cmh.2024.0055
摘要

Background/Aims: Chronic hepatitis B (CHB) is related to an increased risk of extrahepatic malignancy (EHM), and antiviral treatment is associated with an incidence of EHM comparable to controls.We compared the risks of EHM and intrahepatic malignancy (IHM) between entecavir (ETV) and tenofovir disoproxil fumarate (TDF) treatment. Methods:Using data from the National Health Insurance Service of Korea, this nationwide cohort study included treatment-naïve CHB patients who initiated ETV (n=24,287) or TDF (n=29,199) therapy between 2012 and 2014.The primary outcome was the development of any primary EHM.Secondary outcomes included overall IHM development.E-value was calculated to assess the robustness of results to unmeasured confounders. Results:The median follow-up duration was 5.9 years, and all baseline characteristics were well balanced after propensity score matching.EHM incidence rate differed significantly between within versus beyond 3 years in both groups (P<0.1,Davies test).During the first 3 years, EHM risk was comparable in the propensity score-matched cohort (5.88 versus 5.84/1,000 person-years; subdistribution hazard ratio [SHR]=1.01,95% confidence interval[CI]=0.88-1.17,P=0.84).After year 3, however, TDF was associated with a significantly lower EHM incidence compared to ETV (4.92 versus 6.91/1,000 person-years; SHR=0.70,95% CI=0.60-0.81,P<0.01; E-value for SHR=2.21).Regarding IHM, the superiority of TDF over ETV was maintained both within (17.58 versus 20.19/1,000 person-years; SHR=0.88,95% CI=0.81-0.95,P<0.01) and after year 3 (11.45versus 16.20/1,000 person-years; SHR=0.68,95% CI=0.62-0.75,P<0.01; E-value for SHR=2.30).Conclusions: TDF was associated with approximately 30% lower risks of both EHM and IHM than ETV in CHB patients after 3 years of antiviral therapy.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
scholar丨崔发布了新的文献求助10
10秒前
want_top_journal完成签到,获得积分10
26秒前
28秒前
scholar丨崔完成签到,获得积分10
33秒前
35秒前
38秒前
简单的沛蓝完成签到 ,获得积分10
40秒前
JIAN完成签到 ,获得积分10
43秒前
Jasper应助hxn采纳,获得30
44秒前
xxx完成签到,获得积分10
47秒前
53秒前
Green完成签到,获得积分10
55秒前
斐嘿嘿发布了新的文献求助10
56秒前
谢丹完成签到 ,获得积分10
57秒前
寒冷的完成签到,获得积分10
1分钟前
文武完成签到 ,获得积分10
1分钟前
zlf完成签到,获得积分10
1分钟前
1分钟前
1分钟前
香蕉觅云应助科研通管家采纳,获得10
1分钟前
1分钟前
林宥嘉完成签到 ,获得积分10
1分钟前
老夫子完成签到,获得积分10
1分钟前
kenti2023完成签到 ,获得积分10
1分钟前
2分钟前
YYYCCCCC发布了新的文献求助10
2分钟前
2分钟前
11发布了新的文献求助10
2分钟前
CipherSage应助miles采纳,获得10
2分钟前
周游完成签到 ,获得积分10
2分钟前
2分钟前
2分钟前
huihongzeng发布了新的文献求助10
2分钟前
Judy完成签到 ,获得积分10
2分钟前
利物鸟贝拉完成签到,获得积分10
2分钟前
2分钟前
Esperanza完成签到,获得积分10
2分钟前
miles发布了新的文献求助10
2分钟前
2分钟前
鹿茸与共发布了新的文献求助10
2分钟前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3990020
求助须知:如何正确求助?哪些是违规求助? 3532077
关于积分的说明 11256276
捐赠科研通 3270943
什么是DOI,文献DOI怎么找? 1805139
邀请新用户注册赠送积分活动 882270
科研通“疑难数据库(出版商)”最低求助积分说明 809228