姜黄素
壳聚糖
生物利用度
结合
化学
琥珀酸酐
纳米颗粒
溶解度
核化学
纳米技术
有机化学
药理学
材料科学
生物化学
数学分析
医学
数学
作者
Sourour Idoudi,Yousef M. Hijji,Takwa Bedhiafi,Hesham M. Korashy,Shahab Uddin,Maysaloun Merhi,Said Dermime,Nashiru Billa
标识
DOI:10.1016/j.carbpol.2022.120034
摘要
Curcumin (CUR) manifests anti-colon cancer activity but suffers from low solubility, bioavailability, and instability, rendering it not as effective as its chemotherapeutic cousins. Here, we conjugate CUR to succinic anhydride (SA), (CUR.SA conjugate), subsequently formulated in mannose-conjugated chitosan nanoparticles (CUR-NPs and CUR.SA-NPs). Instrumental analyses confirmed formation of CUR.SA and mannosylated chitosan (CM) conjugates, with CUR.SA being less crystalline thus, more soluble. Average particle size of CUR-NPs and CUR.SA-NPs were 268 ± 6 nm and 342 ± 4.6 nm, with drug entrapment of 93.34 ± 0.40 % and 98.46 ± 0.06 % respectively. In vitro releases of CUR and CUR.SA from nanoparticles in pH 1.2 and 6.8 media were slow and sustained over 2 h and 72 h, respectively. The physical characteristics of the nanoparticles were unchanged over 3 weeks of storage. Thus, a successful CUR.SA conjugate has been developed, couriered in CM nanoparticles, with favorable attributes that warrant further anti-colon cancer studies, which is ongoing.
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