Enhancing anti-inflammatory and antibacterial activity of curcumin by nano composing with curcumin reduced copper nano for the treatment of bacterial infection

The interaction of metal nanoparticles with cellular components and biomacromolecules including DNA and RNA and the alteration of cellular processes is an extensively studied field. From the perspective of antimicrobial and antifungal activity it has been proved that at the nanomolar level metal nanoparticles are capable of resisting bacterial strains. Though the mode of action of or rather steps of reactions of metallic nanoparticles as anti-fungal or antibacterial or antimicrobials is not yet fully realized a number of models or courses of action are currently in use. The most appreciated ones are the release of metallic ions to destroy microbial enzymes by alteration of membrane integrity followed by the easy access of metal nanoparticles to be in contact with bacterial cytoplasm and last but most important is the creation of active oxygen species in the periplasmic space which are the result of the influence of metals. This paper represents our study on copper nanoparticles synthesized by using natural reducing agents and reports on the developed antimicrobial properties of chitosan in Escherichia coli.