阿霉素
上睑下垂
自噬
活性氧
DNA损伤
细胞凋亡
癌症
癌症研究
程序性细胞死亡
药理学
免疫系统
医学
化学
化疗
生物
免疫学
细胞生物学
DNA
生物化学
外科
内科学
作者
Mateusz Kciuk,Adrianna Gielecińska,Somdutt Mujwar,Damian Kołat,Żaneta Kałuzińska‐Kołat,İsmail Çeli̇k,Renata Kontek
出处
期刊:Cells
[MDPI AG]
日期:2023-02-19
卷期号:12 (4): 659-659
被引量:222
标识
DOI:10.3390/cells12040659
摘要
Doxorubicin (DOX) constitutes the major constituent of anti-cancer treatment regimens currently in clinical use. However, the precise mechanisms of DOX’s action are not fully understood. Emerging evidence points to the pleiotropic anticancer activity of DOX, including its contribution to DNA damage, reactive oxygen species (ROS) production, apoptosis, senescence, autophagy, ferroptosis, and pyroptosis induction, as well as its immunomodulatory role. This review aims to collect information on the anticancer mechanisms of DOX as well as its influence on anti-tumor immune response, providing a rationale behind the importance of DOX in modern cancer therapy.
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