医学
脂蛋白(a)
药理学
脂蛋白
内科学
传统医学
胆固醇
作者
Michelle L. O’Donoghue,Robert S. Rosenson,J. Antonio G. López,Norman E. Lepor,Seth J. Baum,Elmer Stout,Daniel Gaudet,Beat Knüsel,Julia Kuder,Sabina A. Murphy,Huei Wang,You Wu,Trupti Shah,Jingying Wang,Tomasz Wilmanski,Winnie Sohn,Helina Kassahun,Marc S. Sabatine
标识
DOI:10.1016/j.jacc.2024.05.058
摘要
Olpasiran is a potent siRNA with prolonged effects on Lp(a) lowering. Participants receiving doses ≥75 mg Q12W sustained a ∼40% to 50% reduction in Lp(a) levels close to 1 year after the last dose. (Olpasiran Trials of Cardiovascular Events And LipoproteiN[a] Reduction-DOSE Finding Study [OCEAN(a)-DOSE]; NCT04270760).
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