PARP抑制剂
化学
癌症治疗
药理学
癌症研究
聚ADP核糖聚合酶
癌症
组合化学
纳米技术
医学
生物化学
材料科学
内科学
酶
聚合酶
作者
Bingling Gao,Jing Wang,Manman Yang,Wendong Li,Tingli Jiang,Rong Gao,Yuxin Pei,Zhichao Pei,Yinghua Lv
摘要
A biological nanoplatform (Gal-ANI@ZnAP NPs) was constructed based on a prodrug-skeletal metal-organic framework (MOF) using purine nucleobase analogue prodrug 6-allylthiopurine as a bioactive ligand, and functionalized with AIE fluorescent PARP inhibitor glycoconjugate for visualization therapy and synthetic lethal cancer therapy. This nanoplatform could actively target cancer cells, selectively release drugs in response to esterase/pH, and visualize drug uptake.
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