谷氨酰胺
心肌梗塞
新陈代谢
心室功能
心脏病学
炎症
心室重构
巨噬细胞
内科学
医学
生物化学
化学
氨基酸
体外
作者
Alan J. Mouton,Nikaela Aitken,Jemylle G. Morato,Jussara M. do Carmo,Alexandre A. da Silva,Ana Carolina Mieko Omoto,Xuan Li,Zhen Wang,Alexandra C. Schrimpe‐Rutledge,Simona G. Codreanu,Stacy D. Sherrod,John A. McLean,Joshua Stanford,Jordan Brown,John E. Hall
出处
期刊:American Journal of Physiology-cell Physiology
[American Physiological Society]
日期:2024-07-09
卷期号:327 (3): C571-C586
标识
DOI:10.1152/ajpcell.00272.2024
摘要
Glutamine metabolism is altered in both infarct macrophages and the remote left ventricle (LV) following myocardial infarction (MI). Supplemental glutamine improves LV function following MI while inhibiting glutamine metabolism with BPTES worsens LV function. Supplemental glutamine or BPTES does not impact macrophage immunometabolic phenotypes after MI.
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