化学型
表面改性
电化学
化学
阶段(地层学)
组合化学
生物
色谱法
电极
古生物学
物理化学
精油
作者
Lisa Giannessi,Marcello Longo,Chiara Massera,Marco Radi
摘要
We report the development and application of different strategies for the late-stage functionalization (LSF) of the biologically relevant 4-amino-2-pyridone chemotype. Using the recently discovered PCSK9 inhibitor 5c as a prototype, a series of electrochemical LSF (e-LSF) and multicomponent LSF (MCR-LSF) have been set-up to decorate the 4-amino-2-pyridone scaffold. The usefulness of these methods has been demonstrated by generating a series of novel derivatives in a site-selective and sustainable way.
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