神经刺激
再生(生物学)
角膜上皮
医学
叙述性评论
角膜疾病
角膜
三叉神经
角膜病
神经科学
模式
治疗方式
眼科
外科
重症监护医学
心理学
生物
刺激
物理疗法
内科学
细胞生物学
社会科学
社会学
作者
Taylor N. Drake,John D. Sheppard
出处
期刊:Eye & Contact Lens-science and Clinical Practice
[Ovid Technologies (Wolters Kluwer)]
日期:2024-10-11
标识
DOI:10.1097/icl.0000000000001130
摘要
Abstract: The corneal epithelium, supplied by thousands of nerve endings, plays a substantial role in absorbing and distributing nutrients along the ocular surface. Many studies have explored the influence of various modalities in regulating tear production to manage corneal disorders and dry eye disease. These findings have highlighted the advantages of enhancing corneal nerve function and regeneration through neurostimulation, neural signaling, immunomodulation, topical medication application, and surgical reconstruction. The purpose of this narrative review article was to provide an overview of the current state of knowledge on this topic based on a PubMed database literature search for relevant animal and human studies investigating the modification of the trigeminal pathway to restore corneal nerve function and improve overall ocular health. Further investigation into this area of research is important to help guide new therapeutic targets for the prevention and development of treatments of corneal degeneration.
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