大肠杆菌
纳米复合材料
核化学
金属
细胞毒性
化学
水溶液中的金属离子
抗菌活性
微生物学
材料科学
纳米技术
细菌
有机化学
生物
生物化学
体外
基因
遗传学
作者
Shao-Bo Guo,Xu Liu,NULL AUTHOR_ID,Jiawei Wang,NULL AUTHOR_ID,Tanlei Zhang,NULL AUTHOR_ID,Hao Han,Zhifeng Liu,Ying Bai,Jin Tang
标识
DOI:10.1016/j.jhazmat.2024.135149
摘要
Ag nanocomposites (NAs) have been found to induce irreversible harm to pathogenic bacteria, however, NAs tend to aggregate easily when used alone. These nanocomposites also show increased toxicity and their underlying antibacterial mechanism is still unknown. In short, practical applications of NA materials face the following obstacles: elucidating the mechanism of antibacterial action, reducing cytotoxicity to body cells, and enhancing antibacterial activity. This study synthesized a core-shell structured ZnFe2O4@Cu-ZIF-8@Ag (FUA) nanocomposite with high antibacterial activity and low cytotoxicity. The nanocomposites achieved a 99.99% antibacterial rate against Escherichia coli (E. coli) and tetracycline-resistant E. coli (T - E. coli), in under 20 min at 100 μg/mL. The nanocomposites were able to inactivate E. coli due to the gradual release of Cu2+, Zn2+, and Ag+ ions, which synergistically form •OH from FUA in an aerobic environment. The presence of •OH has significant effects on the antibacterial activity. The released metal ions combine with •OH to cause damage to the bacterial cell wall, resulting in the leakage of electrolytes and ions. Moreover, in comparison to NA, the toxicity of FUA is considerably reduced. This study is expected to inspire the development of other silver-based nanocomposite materials for the inactivation of drug-resistant bacteria.
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