抗坏血酸
化学
兴奋剂
共沉淀
检出限
吸光度
过氧化物酶
生物传感器
纳米技术
氧化还原
显色的
化学发光
催化作用
组合化学
无机化学
化学工程
材料科学
酶
光电子学
物理化学
色谱法
有机化学
工程类
食品科学
作者
Boyu Yan,Ying Yang,Yu Xie,Jinzhao Li,Kun Li
出处
期刊:Chemistry
[MDPI AG]
日期:2023-05-23
卷期号:5 (2): 1302-1316
被引量:2
标识
DOI:10.3390/chemistry5020088
摘要
Although significant advances have been witnessed in the application of nanozymes in recent years, exploring new strategies to enhance the enzyme-like activity of nanozymes is of urgent importance. Herein, we investigate the feasibility of accelerating the peroxidase-like reaction rate of CuO nanostructures through Fe doping. The coprecipitation method was used to synthesize Fe-doped CuO (Fe-CuO) nanozymes, and the results indicate that the diversified valence of Fe benefits the redox reaction driven by CuO-based nanozymes. With the improved peroxidase-like activity, the Fe-CuO nanozyme enables the significant chromogenic oxidation reaction of 3,3′,5,5′-tetramethylbenzidine (TMB), facilitating the construction of a visual sensing platform for the sensitive and selective determination of ascorbic acid. Under optimal conditions, the absorbance at 652 nm decreases linearly with the concentration of ascorbic acid in the range of 5–50 μM, with a limit of detection as low as 4.66 μM. This work exemplifies the activity enhancement for peroxidase-mimicking nanozymes with a metal-doping strategy and provides a broad prospect for the design of more high-performance nanozymes for biosensing applications.
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