胰岛素抵抗
医学
全身炎症
银屑病
炎症
内科学
冠状动脉粥样硬化
生物标志物
亚临床感染
代谢综合征
心脏病学
糖尿病
冠状动脉疾病
队列
高密度脂蛋白
胰岛素
内分泌学
胆固醇
免疫学
肥胖
生物
生物化学
作者
Emilio Berna‐Rico,Carlota Abbad‐Jaime de Aragón,Asunción Ballester-Martinez,Javier Perez‐Bootello,Jorge Solı́s,Leticia Fernández‐Friera,Mar Llamas‐Velasco,María Castellanos‐González,María G. Barderas,Carlos Azcárraga‐Llobet,Emilio Garcia‐Mouronte,Belén de Nicolás-Ruanes,Jorge Naharro‐Rodriguez,Pedro Jaen-Olasolo,Joel M. Gelfand,Nehal N. Mehta,Álvaro González‐Cantero
标识
DOI:10.1016/j.jid.2024.02.015
摘要
Systemic inflammation or insulin resistance drive atherosclerosis. However, they are difficult to capture for assessing cardiovascular risk in clinical settings. The monocyte-to-high-density lipoprotein ratio (MHR) is an accessible biomarker that integrates inflammatory and metabolic information and has been associated with poorer cardiovascular outcomes. Our aim was to evaluate the association of MHR with the presence of subclinical atherosclerosis in patients with psoriasis. The study involved a European and an American cohort including 405 patients with the disease. Subclinical atherosclerosis was assessed by coronary computed tomography angiography. First, MHR correlated with insulin resistance through homeostatic model assessment for insulin resistance, with high-sensitivity CRP and with
科研通智能强力驱动
Strongly Powered by AbleSci AI