A skin-interfaced, miniaturized platform for triggered induction, capture and colorimetric multicomponent analysis of microliter volumes of sweat

汗水 微流控 离子导入 计算机科学 生物医学工程 计算机硬件 纳米技术 材料科学 医学 内科学 放射科
作者
Joohee Kim,Seyong Oh,Dong Yang,Larissa Rugg,Radhika Mathur,Sung Soo Kwak,Seonggwang Yoo,Shupeng Li,Evangelos E. Kanatzidis,Geumbee Lee,Hong‐Joon Yoon,Yonggang Huang,Roozbeh Ghaffari,Susanna A. McColley,John A. Rogers
出处
期刊:Biosensors and Bioelectronics [Elsevier]
卷期号:253: 116166-116166 被引量:3
标识
DOI:10.1016/j.bios.2024.116166
摘要

Eccrine sweat can serve as a source of biomarkers for assessing physiological health and nutritional balance, for tracking loss of essential species from the body and for evaluating exposure to hazardous substances. The growing interest in this relatively underexplored class of biofluid arises in part from its non-invasive ability for capture and analysis. The simplest devices, and the only ones that are commercially available, exploit soft microfluidic constructs and colorimetric assays with purely passive modes of operation. The most sophisticated platforms exploit batteries, electronic components and radio hardware for inducing sweat, for electrochemical evaluation of its content and for wireless transmission of this information. The work reported here introduces a technology that combines the advantages of these two different approaches, in the form of a cost-effective, easy-to-use device that supports on-demand evaluation of multiple biomarkers in sweat. This flexible, skin-interfaced, miniaturized system incorporates a hydrogel that contains an approved drug to activate eccrine sweat glands, electrodes and a simple circuit and battery to delivery this drug by iontophoresis through the surface of the skin, microfluidic channels and microreservoirs to capture the induced sweat, and multiple colorimetric assays to evaluate the concentrations of chloride, zinc, and iron. As demonstrated in healthy human participants monitored before and after a meal, such devices yield results that match those of traditional laboratory analysis techniques. Clinical studies that involve cystic fibrosis pediatric patients illustrate the use of this technology as a simple, painless, and reliable alternative to traditional hospital systems for measurements of sweat chloride.
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