Photocatalytic enantioselective radical transformation enabled by radical–polar crossover

Asymmetric transformation of radicals has always been recognized as a highly challenging issue, compared with the well-developed enantioinduction methods in traditional polar/ionic chemistry. Enantioselective radical polar crossover (RPC) reactions have recently emerged as valuable and powerful tools to assemble molecular complexity that would be impossible using either a radical or polar approach alone. This chapter summarizes the recent and synthetically important stereoselective RPC transformations by merging photoredox catalysis.