自愈水凝胶
纳米技术
伤口愈合
材料科学
纳米颗粒
生物医学工程
计算机科学
医学
外科
高分子化学
作者
Yuxiang Wang,Mengya Zhang,Zhenzhen Yan,Shizhao Ji,Shichu Xiao,Jie Gao
出处
期刊:Theranostics
[Ivyspring International Publisher]
日期:2024-01-01
卷期号:14 (4): 1534-1560
被引量:6
摘要
Wounds represent a grave affliction that profoundly impacts human well-being.Establishing barriers, preventing infections, and providing a conducive microenvironment constitute the crux of wound therapy.Hydrogel, a polymer with an intricate three-dimensional lattice, serves as a potent tool in erecting physical barriers and nurturing an environment conducive to wound healing.This enables effective control over exudation, hemostasis, accelerated wound closure, and diminished scar formation.As a result, hydrogels have gained extensive traction in the realm of wound treatment.Metallic nanoparticle carriers, characterized by their multifaceted responses encompassing acoustics, optics, and electronics, have demonstrated efficacy in wound management.Nevertheless, these carriers encounter challenges associated with swift clearance and nonuniform effectiveness.The hybridization of metallic nanoparticle carriers with hydrogels overcomes the shortcomings inherent in metallic nanoparticle-based wound therapy.This amalgamation not only addresses the limitations but also augments the mechanical robustness of hydrogels.It confers upon them attributes such as environmental responsiveness and multifunctionality, thereby synergizing strengths and compensating for weaknesses.This integration culminates in the precise and intelligent management of wounds.This review encapsulates the structural classifications, design strategies, therapeutic applications, and underlying mechanisms of metal nanoparticle hybrid hydrogels in the context of acute and chronic wound treatment.The discourse delves into the generation of novel or enhanced attributes arising from hybridization and how the current paradigm of wound therapy leverages these attributes.Amidst this continually evolving frontier, the potential of metal nanoparticle hybrid hydrogels to revolutionize wound treatment is underscored.
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