肝细胞癌
癌症研究
整合素
癌症
癌相关成纤维细胞
癌细胞
细胞内
肿瘤微环境
化学
细胞生物学
医学
肿瘤细胞
生物
细胞
内科学
生物化学
作者
Zheng Peng,Yanling Ding,Hongyu Zhang,Meng Xia,Yiyong Huang,Pengfei Zhang,Zepeng Li,Xiaoling Zhou
出处
期刊:Journal of Cancer Metastasis and Treatment
[OAE Publishing Inc.]
日期:2024-01-22
标识
DOI:10.20517/2394-4722.2023.137
摘要
Mechanical forces play a key role in the initiation and progression of cancer. Intercellular interactions between fibroblasts and cancer cells contribute a large portion of the mechanical forces in tumor tissue. Hence, further investigation of the mechanical force-mediated intercellular interactions between cancer cells and fibroblasts is urgently needed, given the slow progress in the management of various solid cancers. In our previous study, we observed obvious mechanical force-mediated interactions between hepatocellular carcinoma (HCC) cells and fibroblasts through integrins and ECM proteins by using our coculture model and discovered that these interactions play important roles in 3D structure formation and tumor growth, suggesting their potential application in HCC treatment. In this review, we summarize the recent research progress in this field in hopes of providing insight into the development of potential anticancer strategies, with a special focus on HCC.
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