纳米载体
癌变
壳聚糖
内吞作用
乳腺癌
免疫疗法
癌症研究
癌症
纳米医学
药物输送
癌症治疗
纳米颗粒
纳米技术
癌细胞
化学
材料科学
医学
内科学
细胞
生物化学
作者
Tianfeng Li,Milad Ashrafizadeh,Yuru Shang,Yavuz Nuri Ertaş,Gorka Orive
标识
DOI:10.1016/j.drudis.2023.103851
摘要
Breast cancer is the most common and malignant tumor among women. Chitosan (CS)-based nanoparticles have been introduced into breast cancer therapy as a way to increase the targeted delivery of drugs and genes to the tumor site. CS nanostructures suppress tumorigenesis by enhancing both the targeted delivery of cargo (drug and gene) and its accumulation in tumor cells. The tumor cells internalize CS-based nanoparticles through endocytosis. Moreover, chitosan nanocarriers can also induce phototherapy-mediated tumor ablation. Smart and multifunctional types of CS nanoparticles, including pH-, light- and redox-responsive nanoparticles, can be used to improve the potential for breast cancer removal. In addition, the acceleration of immunotherapy by CS nanoparticles has also been achieved, and there is potential to develop CS-nanoparticle hydrogels that can be used to suppress tumorigenesis.
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