‘Why is survival with triple negative breast cancer so low? insights and talking points from preclinical and clinical research’

三阴性乳腺癌 乳腺癌 医学 机制(生物学) 肿瘤科 抗药性 癌症 癌症研究 生物信息学 内科学 生物 微生物学 认识论 哲学
作者
Maria Ilenia Passalacqua,Graziella Rizzo,Mariacarmela Santarpía,Giuseppe Curigliano
出处
期刊:Expert Opinion on Investigational Drugs [Informa]
卷期号:31 (12): 1291-1310 被引量:2
标识
DOI:10.1080/13543784.2022.2159805
摘要

Triple negative breast cancer is typically related to poor prognosis, early metastasis, and high recurrence rate. Intrinsic and extrinsic biological features of TNBC and resistance mechanisms to conventional therapies can support its aggressive behavior, characterizing TNBC how extremely heterogeneous. Novel combination strategies are under investigation, including immunotherapeutic agents, anti-drug conjugates, PARP inhibitors, and various targeting agents, exploring, in the meanwhile, possible predictive biomarkers to correctly select patients for the optimal treatment for their specific subtype.This article examines the main malignity characteristics across different subtype, both histological and molecular, and the resistance mechanisms, both primary and acquired, to different drugs explored in the landscape of TNBC treatment, that lead TNBC to still has high mortality rate.The complexity of TNBC is not only the main reason of its aggressivity, but its heterogeneity should be exploited in terms of therapeutics opportunities, combining agents with different mechanism of action, after a correct selection by biologic or molecular biomarkers. The main goal is to understand what TNBC really is and to act selectively on its characteristics, with a personalized anticancer treatment.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
jm完成签到,获得积分10
1秒前
1秒前
1秒前
都是发布了新的文献求助10
2秒前
猪猪hero应助wp采纳,获得10
3秒前
4秒前
4秒前
5秒前
5秒前
6秒前
6秒前
6秒前
yaoyao完成签到,获得积分20
6秒前
6秒前
夏天来了发布了新的文献求助10
6秒前
研友_VZG7GZ应助月光闪采纳,获得10
7秒前
周老二发布了新的文献求助30
7秒前
乐乐应助科研通管家采纳,获得10
8秒前
orixero应助科研通管家采纳,获得10
8秒前
科研通AI5应助科研通管家采纳,获得10
8秒前
深情安青应助科研通管家采纳,获得10
8秒前
隐形曼青应助科研通管家采纳,获得10
8秒前
领导范儿应助科研通管家采纳,获得10
8秒前
Hello应助科研通管家采纳,获得10
8秒前
科研通AI5应助科研通管家采纳,获得10
8秒前
wanci应助科研通管家采纳,获得10
8秒前
Jasper应助科研通管家采纳,获得10
8秒前
打打应助科研通管家采纳,获得10
9秒前
Hello应助科研通管家采纳,获得10
9秒前
9秒前
科研通AI5应助科研通管家采纳,获得10
9秒前
wanci应助科研通管家采纳,获得10
9秒前
传奇3应助科研通管家采纳,获得10
9秒前
怕黑荠应助科研通管家采纳,获得30
9秒前
怕黑荠应助科研通管家采纳,获得30
9秒前
zl应助科研通管家采纳,获得20
9秒前
李嘉乐发布了新的文献求助10
9秒前
bkagyin应助科研通管家采纳,获得10
9秒前
星辰大海应助科研通管家采纳,获得10
9秒前
大个应助科研通管家采纳,获得10
9秒前
高分求助中
Continuum Thermodynamics and Material Modelling 3000
Production Logging: Theoretical and Interpretive Elements 2700
Les Mantodea de Guyane Insecta, Polyneoptera 1000
Structural Load Modelling and Combination for Performance and Safety Evaluation 1000
Conference Record, IAS Annual Meeting 1977 820
電気学会論文誌D(産業応用部門誌), 141 巻, 11 号 510
Typology of Conditional Constructions 500
热门求助领域 (近24小时)
化学 材料科学 生物 医学 工程类 有机化学 生物化学 物理 纳米技术 计算机科学 内科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 量子力学 光电子学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3570542
求助须知:如何正确求助?哪些是违规求助? 3141299
关于积分的说明 9442455
捐赠科研通 2842608
什么是DOI,文献DOI怎么找? 1562356
邀请新用户注册赠送积分活动 731072
科研通“疑难数据库(出版商)”最低求助积分说明 718272